{"id":"W2785540442","doi":"10.1016/j.cmet.2018.01.004","title":"Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation","year":2018,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":289,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Novo Nordisk Fonden; European Research Council; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Svenska Sällskapet för Medicinsk Forskning; Wenner-Gren Stiftelserna; Wellcome Trust; Stichting af Jochnick Foundation; Karolinska Institutet; Familjen Erling-Perssons Stiftelse","keywords":"Kynurenic acid; Kynurenine; Adipose tissue; Kynurenine pathway; Energy homeostasis; Endocrinology; Internal medicine; Biology; Glucose homeostasis; Inflammation; White adipose tissue; Carbohydrate metabolism; Chemistry; Receptor; Biochemistry; Medicine; Insulin resistance; Glutamate receptor; Tryptophan","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537208,0.000256085,0.0002878848,0.0002124024,0.0002242318,0.0005225776,0.0002082849,0.000422405,0.001187952],"category_scores_gemma":[0.0001758252,0.0001208424,0.0003212919,0.0001156841,0.0003455356,0.0004555619,0.0004977517,0.0003860557,0.0002427769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004495382,"about_ca_system_score_gemma":0.0002709148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001640831,"about_ca_topic_score_gemma":0.002034562,"domain_scores_codex":[0.9998789,0.00003091948,0.000006982299,0.0000227437,0.00001516948,0.00004525623],"domain_scores_gemma":[0.9999571,0.00000491297,0.00001293465,0.000003855528,0.00000738749,0.00001379659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004149947,0.0001061572,0.006881976,0.0002596813,0.0001579764,0.001138221,0.0003701461,0.0005968826,0.9483746,0.004662688,0.001261837,0.03203991],"study_design_scores_gemma":[0.0006469173,0.002254972,0.3463253,0.0002309877,0.0005848308,0.007892514,0.003005699,0.009539255,0.5543157,0.01703274,0.05802048,0.0001506786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773275,0.01558011,0.003025116,0.0008712676,0.00008504011,0.00002084904,0.0002746762,0.00005934928,0.002756109],"genre_scores_gemma":[0.9933435,0.002881059,0.001384681,0.0001404544,0.0000222596,0.00001039738,0.0001712138,0.00001008235,0.002036413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001640831,"threshold_uncertainty_score":0.00397408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01175790207761484,"score_gpt":0.2270526196710643,"score_spread":0.2152947175934495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}