{"id":"W2785752848","doi":"10.1074/jbc.ra117.001097","title":"Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Institute of Genetics; Canadian Institutes of Health Research","keywords":"Calpain; Protease; Protease inhibitor (pharmacology); Chemistry; Calpastatin; Biophysics; Biochemistry; Enzyme; Biology; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031796,0.0003134192,0.0003088441,0.0001814129,0.0002912376,0.0003992788,0.0005390137,0.000620582,0.0020378],"category_scores_gemma":[0.0003116734,0.0002117898,0.0003699638,0.0002841541,0.0002499497,0.0004633388,0.0001690061,0.001313658,0.0003818648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001042633,"about_ca_system_score_gemma":0.0005168801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003612941,"about_ca_topic_score_gemma":0.002602429,"domain_scores_codex":[0.999939,0.000007252186,0.000003078123,0.00001185935,0.00002269406,0.00001613929],"domain_scores_gemma":[0.9998659,0.0000279034,0.00003759601,0.00001474566,0.00001650373,0.00003745308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001851088,0.0002302145,0.0009926285,0.0002208982,0.00007559013,0.0006042879,0.000232342,0.004061267,0.9790193,0.003984326,0.001921925,0.006805955],"study_design_scores_gemma":[0.0008783951,0.0009230701,0.03486226,0.00008880986,0.0001759242,0.002930605,0.0002428096,0.05965006,0.8679637,0.003848655,0.02833164,0.0001040616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725968,0.004670508,0.01165249,0.000671803,0.0001132483,0.00006745472,0.001848644,0.0004134894,0.0079656],"genre_scores_gemma":[0.9831741,0.001169674,0.008893167,0.0002395388,0.00001518754,0.00003132434,0.003714811,0.00006504434,0.002697107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003612941,"threshold_uncertainty_score":0.007564902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792721007281155,"score_gpt":0.263505303469058,"score_spread":0.2455780933962465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}