{"id":"W2785928421","doi":"10.1155/2018/2781789","title":"Clinical Relapses of Atypical HUS on Eculizumab: Clinical Gap for Monitoring and Individualised Therapy","year":2018,"lang":"en","type":"article","venue":"Case Reports in Nephrology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Eculizumab; Atypical hemolytic uremic syndrome; Medicine; Complement system; Thrombotic microangiopathy; Intensive care medicine; Monoclonal; Monoclonal antibody; Immunology; Internal medicine; Antibody; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001871083,0.0006068844,0.001180171,0.0006685915,0.0007030932,0.001132185,0.0007882926,0.001938597,0.001075452],"category_scores_gemma":[0.006656337,0.000283099,0.0003683683,0.0004293679,0.00098619,0.001926546,0.0007243317,0.002558646,0.0003841987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008091674,"about_ca_system_score_gemma":0.0008158991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009994222,"about_ca_topic_score_gemma":0.001145124,"domain_scores_codex":[0.9987728,0.0003668042,0.0002298285,0.0001476442,0.0002678971,0.0002150057],"domain_scores_gemma":[0.9963158,0.001785451,0.000659748,0.0001906378,0.0004694242,0.0005789571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.000953767,0.000381193,0.1511643,0.0006112077,0.00007134388,0.6889072,0.002171603,0.0009169052,0.007781054,0.003281992,0.01166393,0.1320956],"study_design_scores_gemma":[0.0001163128,0.0005691772,0.09428976,0.001650761,0.0001887182,0.870145,0.00290143,0.003415454,0.002373343,0.004569769,0.0196615,0.0001187086],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8419107,0.07377225,0.01040403,0.04829541,0.0007676609,0.000337123,0.0002513389,0.0003341624,0.02392724],"genre_scores_gemma":[0.982989,0.009117357,0.002714774,0.003323237,0.00117102,0.00003244423,0.0001137917,0.00003020662,0.0005081801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001938597,"threshold_uncertainty_score":0.009895325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1187623716497601,"score_gpt":0.4167781160844957,"score_spread":0.2980157444347356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}