{"id":"W2785928421","doi":"10.1155/2018/2781789","title":"Clinical Relapses of Atypical HUS on Eculizumab: Clinical Gap for Monitoring and Individualised Therapy","year":2018,"lang":"en","type":"article","venue":"Case Reports in Nephrology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Eculizumab; Atypical hemolytic uremic syndrome; Medicine; Complement system; Thrombotic microangiopathy; Intensive care medicine; Monoclonal; Monoclonal antibody; Immunology; Internal medicine; Antibody; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001893484,0.0002070787,0.0007563947,0.0001505325,0.0001218048,0.000007098511,0.0001042944,0.0005437367,0.0002162507],"category_scores_gemma":[0.001261089,0.0001810998,0.0001995332,0.00009065966,0.001151565,0.00004255194,0.0001281903,0.0003160372,0.00001737062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002352531,"about_ca_system_score_gemma":0.0001148646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003686863,"about_ca_topic_score_gemma":0.00003802576,"domain_scores_codex":[0.996318,0.0007936145,0.001802951,0.0006523986,0.00004673079,0.0003863348],"domain_scores_gemma":[0.9963127,0.002257448,0.0006227354,0.0006125602,0.0001366573,0.00005786795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004752406,0.0009120909,0.9546213,0.00004391831,0.0004537891,0.004902618,0.0002493902,0.000001093014,0.002349579,0.00072673,0.009999803,0.02098734],"study_design_scores_gemma":[0.0116292,0.009444238,0.7694507,0.0002121602,0.000198458,0.03017636,0.0004156991,0.000008290644,0.005797889,0.00301408,0.1690858,0.000567087],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938695,0.001823818,0.0000309642,0.0001277827,0.003045672,0.0007944946,0.00002794322,0.00004492335,0.0002349177],"genre_scores_gemma":[0.9985949,0.0001913051,0.000278885,0.000254857,0.0004561909,0.00009962317,0.0000290781,0.00002206712,0.00007313454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1851706,"threshold_uncertainty_score":0.7385035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1187623716497601,"score_gpt":0.4167781160844957,"score_spread":0.2980157444347356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}