{"id":"W2785943060","doi":"10.7554/elife.32656","title":"AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis","year":2018,"lang":"en","type":"article","venue":"eLife","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Medical Research Council; State Government of Victoria; National Health and Medical Research Council; Medical Research Council Canada; Canada Research Chairs","keywords":"Orexigenic; AMPK; Acetyl-CoA carboxylase; Endocrinology; Appetite; Internal medicine; Thermogenesis; Ghrelin; AMP-activated protein kinase; Energy homeostasis; Phosphorylation; Protein kinase A; Pyruvate carboxylase; Chemistry; Lipogenesis; Biology; Medicine; Receptor; Lipid metabolism; Adipose tissue; Biochemistry; Hormone; Enzyme; Neuropeptide Y receptor; Neuropeptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002920335,0.0001968495,0.0003751463,0.00009787043,0.0001604119,0.00002273309,0.00008991542,0.0001175645,0.00008593739],"category_scores_gemma":[0.0002527184,0.000174727,0.00007937734,0.0001625762,0.00005279929,0.00005633016,0.00006415649,0.00007561414,0.000122675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002407724,"about_ca_system_score_gemma":0.00009160556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001202463,"about_ca_topic_score_gemma":0.00001659957,"domain_scores_codex":[0.9986663,0.00002488357,0.0002659609,0.0003935781,0.0002686998,0.0003806182],"domain_scores_gemma":[0.9989039,0.00008499342,0.00008030108,0.0003301656,0.0002516538,0.000349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002692016,0.00002993869,0.0004343577,0.00006250555,0.000081252,0.000007391606,0.001734895,3.035884e-7,0.9880891,0.00006274458,0.001648108,0.007580139],"study_design_scores_gemma":[0.001532754,0.0005337463,0.003908126,0.0001436397,0.0002689099,0.00001537915,0.0001876207,0.00009911906,0.9450641,0.000006680638,0.04803322,0.0002067379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950071,0.0004464375,0.0008387663,0.001944584,0.0003013716,0.0007980815,0.00004597566,0.00009207428,0.0005255844],"genre_scores_gemma":[0.9823093,0.00003173103,0.003915227,0.007307112,0.001973518,0.00007186191,0.000006290949,0.00005805475,0.004326857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04638511,"threshold_uncertainty_score":0.7125162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04876685751625702,"score_gpt":0.310865055723463,"score_spread":0.2620981982072059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}