{"id":"W2785993555","doi":"10.1039/c8md00009c","title":"Membrane activity profiling of small molecule <i>B. subtilis</i> growth inhibitors utilizing novel duel-dye fluorescence assay","year":2018,"lang":"en","type":"article","venue":"MedChemComm","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto; Toronto Public Health","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Small molecule; Fluorescence; Depolarization; Membrane; Chemistry; Biophysics; Profiling (computer programming); Biochemistry; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005266438,0.0003136821,0.0005045081,0.0001166399,0.0002712695,0.00002268861,0.0003959543,0.0003177188,0.000171877],"category_scores_gemma":[0.0002619054,0.0002877831,0.0001808948,0.0002501497,0.000898392,0.000199675,0.0002676848,0.0004579845,0.00009782481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004179067,"about_ca_system_score_gemma":0.00008894069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005488927,"about_ca_topic_score_gemma":0.00007345922,"domain_scores_codex":[0.9983764,0.0001530318,0.0003815269,0.000451696,0.00007033526,0.0005670658],"domain_scores_gemma":[0.9988179,0.0002388899,0.0002737674,0.000405388,0.0002218602,0.00004225805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001801738,0.0002869992,0.001913617,0.000106448,0.00009597724,0.000002563912,0.0003909705,6.288859e-7,0.9943715,0.0006928467,0.000847992,0.001110286],"study_design_scores_gemma":[0.0008018626,0.0001464266,0.0006111457,0.0001347537,0.00004584649,0.00003296691,0.0003158917,0.0000429373,0.9968241,0.00002591109,0.0007222064,0.0002959129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912694,0.000171245,0.001708347,0.0002797792,0.0007359242,0.0002842858,0.00006733878,0.0001265426,0.005357099],"genre_scores_gemma":[0.9965416,0.00003350513,0.002400375,0.0001555401,0.0001304096,0.00001203501,0.00004440746,0.00003891638,0.0006432373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005272136,"threshold_uncertainty_score":0.9999574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02063440557088255,"score_gpt":0.2306964444990033,"score_spread":0.2100620389281207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}