{"id":"W2786064307","doi":"10.1161/atvbaha.117.310676","title":"Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient ( <i>LDLR</i> <sup>+/−</sup> and <i>LDLR</i> <sup>−/−</sup> ) Yucatan Miniature Pigs","year":2018,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Esperion Therapeutics","keywords":"LDL receptor; Low-density lipoprotein; Internal medicine; Cholesterol; Endocrinology; Lipoprotein; Chemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009535564,0.0009988897,0.001230157,0.0002115718,0.0006791282,0.0002705864,0.0004709089,0.00109355,0.00005404126],"category_scores_gemma":[0.0001994413,0.0008944759,0.0003370317,0.0003620576,0.00156265,0.0000844808,0.0008483869,0.0005603394,0.00002752784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007105048,"about_ca_system_score_gemma":0.0000654109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310083,"about_ca_topic_score_gemma":0.0007611631,"domain_scores_codex":[0.994828,0.0005610264,0.0008187522,0.002267837,0.0003255383,0.001198777],"domain_scores_gemma":[0.9977052,0.00007655847,0.0003218333,0.001259835,0.0002203446,0.000416274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001110407,0.000405456,0.05203194,0.0001934848,0.0003962363,4.49832e-7,0.001520843,0.000007314819,0.9372855,0.00002525992,0.0006487168,0.00737378],"study_design_scores_gemma":[0.003642825,0.002457596,0.7066976,0.0007062932,0.0002797365,0.00001736775,0.001896294,0.0004212549,0.275436,0.00009121545,0.006241411,0.002112394],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957824,0.001014359,0.00006432914,0.001515663,0.0002088855,0.001082535,0.0002289153,0.0000670712,0.00003587725],"genre_scores_gemma":[0.989248,0.007174027,0.0006688665,0.001815061,0.0005860552,0.0001277584,0.0002406881,0.000110558,0.00002894005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6618494,"threshold_uncertainty_score":0.9993506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158797379178371,"score_gpt":0.2297555352440762,"score_spread":0.2181675614522925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}