{"id":"W2786064307","doi":"10.1161/atvbaha.117.310676","title":"Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient ( <i>LDLR</i> <sup>+/−</sup> and <i>LDLR</i> <sup>−/−</sup> ) Yucatan Miniature Pigs","year":2018,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Esperion Therapeutics","keywords":"LDL receptor; Low-density lipoprotein; Internal medicine; Cholesterol; Endocrinology; Lipoprotein; Chemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003664217,0.0009007508,0.0007614082,0.000711372,0.0003222094,0.0004091074,0.0005014039,0.0008800317,0.001609473],"category_scores_gemma":[0.0002539277,0.0004588001,0.000608004,0.0002029324,0.0006807373,0.0003915293,0.0002291195,0.00124375,0.0004566416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004542453,"about_ca_system_score_gemma":0.0003687837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001283579,"about_ca_topic_score_gemma":0.001739551,"domain_scores_codex":[0.9996523,0.00008293882,0.00004418003,0.0000674953,0.00006976094,0.00008336044],"domain_scores_gemma":[0.9994962,0.00005966317,0.0001789283,0.00004773805,0.00004707702,0.0001703656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001884239,0.0003842945,0.0002769549,0.00004097826,0.00002117123,0.00005442972,0.00001382031,0.00003287562,0.996614,0.00003013144,0.0000477237,0.0005993147],"study_design_scores_gemma":[0.00153774,0.0173713,0.01910109,0.00003110202,0.0002741182,0.0006408516,0.0001392513,0.00141671,0.9573168,0.00007821905,0.002052506,0.00004032177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998217,0.0004018912,0.0005321811,0.0001263283,0.00003566251,0.0000335892,0.0002642632,0.00006127969,0.0003277334],"genre_scores_gemma":[0.9905401,0.001040606,0.002559085,0.0002903556,0.00005001448,0.000163083,0.001145407,0.00008006077,0.004131244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001609473,"threshold_uncertainty_score":0.005384207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158797379178371,"score_gpt":0.2297555352440762,"score_spread":0.2181675614522925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}