{"id":"W2786220274","doi":"10.1172/jci94956","title":"Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Inselspital, Universitätsspital Bern; Université de Lausanne; University of Bern; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"GATA1; Erythropoiesis; Biology; Messenger RNA; Translation (biology); Molecular biology; Polysome; Gene knockdown; Cell biology; Protein biosynthesis; Ribosome; Gene; RNA; Stem cell; Haematopoiesis; Genetics; Internal medicine; Anemia; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009548254,0.00008725397,0.0001987364,0.0000348354,0.00008472589,0.00003370742,0.0001145695,0.0001694224,0.00003487426],"category_scores_gemma":[0.0005526303,0.0000740274,0.0001602028,0.00008363341,0.0003319458,0.00002176263,0.00001014155,0.0001288103,0.000008845703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009952215,"about_ca_system_score_gemma":0.000130927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000530605,"about_ca_topic_score_gemma":0.000006183252,"domain_scores_codex":[0.9985172,0.0001445051,0.0009055744,0.0001549458,0.0001742551,0.000103532],"domain_scores_gemma":[0.9985496,0.0000597746,0.000638183,0.0001656005,0.0004369284,0.0001498899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004796925,0.0001120955,0.006251588,0.00001099218,0.0001157961,9.429127e-7,0.00007802847,0.00005835791,0.8995216,0.00009937245,0.0565695,0.03670201],"study_design_scores_gemma":[0.004430803,0.002664703,0.01632641,0.0001366978,0.0002038445,0.00002763275,0.0001448304,0.00284952,0.7499681,0.003260121,0.219617,0.0003703521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898595,0.0008777093,0.00641431,0.002090886,0.0004907603,0.00007892342,0.00001054177,0.000004806853,0.0001725232],"genre_scores_gemma":[0.9929273,0.0003325425,0.003612726,0.0006440998,0.002278453,0.000002048322,0.00003471799,0.00001327098,0.0001548091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1630475,"threshold_uncertainty_score":0.301875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0509110359829812,"score_gpt":0.3522489635023838,"score_spread":0.3013379275194026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}