{"id":"W2786220274","doi":"10.1172/jci94956","title":"Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Inselspital, Universitätsspital Bern; Université de Lausanne; University of Bern; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"GATA1; Erythropoiesis; Biology; Messenger RNA; Translation (biology); Molecular biology; Polysome; Gene knockdown; Cell biology; Protein biosynthesis; Ribosome; Gene; RNA; Stem cell; Haematopoiesis; Genetics; Internal medicine; Anemia; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001531365,0.0002626407,0.0001619822,0.0001813351,0.0001140585,0.0002567272,0.0001343659,0.0001443445,0.0007677791],"category_scores_gemma":[0.0001302906,0.0001202605,0.0001134794,0.00007272197,0.0002201737,0.0001003241,0.0001203835,0.0002789459,0.0002972729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002749575,"about_ca_system_score_gemma":0.0001665357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002039039,"about_ca_topic_score_gemma":0.000379365,"domain_scores_codex":[0.9999115,0.00001844571,0.00000662045,0.00002633301,0.00001832582,0.00001864804],"domain_scores_gemma":[0.9999311,0.00001192865,0.00003043663,0.000004638446,0.000006606761,0.00001536058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000760142,0.00001237986,0.0008200805,0.00002979991,0.000003262884,0.00005087787,0.00001031403,0.00004905983,0.9949225,0.0001683667,0.00007617639,0.003781159],"study_design_scores_gemma":[0.00001303067,0.0001903304,0.01545735,0.000007791261,0.00001466431,0.0004342387,0.00001962809,0.0008615287,0.9787435,0.0001267772,0.004126862,0.000004307144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979323,0.01133611,0.004952777,0.0002752893,0.00005096422,0.00002999811,0.0003502942,0.0002181632,0.003463251],"genre_scores_gemma":[0.9917991,0.003051342,0.00229243,0.00006239605,0.00001659028,0.00001455525,0.0002271844,0.000025636,0.002510752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007677791,"threshold_uncertainty_score":0.002568424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0509110359829812,"score_gpt":0.3522489635023838,"score_spread":0.3013379275194026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}