{"id":"W2786537973","doi":"10.1126/science.aan0814","title":"<i>C1orf106</i> is a colitis risk gene that regulates stability of epithelial adherens junctions","year":2018,"lang":"en","type":"article","venue":"Science","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Canada Foundation for Innovation; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust; Crohn's and Colitis Foundation of America","keywords":"Adherens junction; Inflammatory bowel disease; Colitis; Ulcerative colitis; Tight junction; Gene; Inflammatory Bowel Diseases; Gastrointestinal tract; Inflammation; Cadherin; Biology; Immunology; Cancer research; Disease; Medicine; Cell biology; Genetics; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004697455,0.00009466775,0.00007995551,0.0000353761,0.0002440471,0.00002232384,0.0003181535,0.00005659804,0.0001791355],"category_scores_gemma":[0.0002070456,0.00008730509,0.00006748408,0.0001830913,0.001883209,0.00001076164,0.0001587121,0.00004160805,0.00004090107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000193293,"about_ca_system_score_gemma":0.0003418049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004786612,"about_ca_topic_score_gemma":0.0001339441,"domain_scores_codex":[0.9989032,0.00004888671,0.0001458146,0.0003982263,0.0002410689,0.0002628492],"domain_scores_gemma":[0.9988368,0.000006223498,0.0001038961,0.0006043998,0.0003192476,0.0001295061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009391261,0.00004114537,0.06108628,0.000008399446,0.000009039129,0.000001501305,0.0001645412,0.000001542163,0.9374579,0.00004112237,0.0006381214,0.0004564476],"study_design_scores_gemma":[0.0001474202,0.00008022876,0.3224512,0.000003612945,0.000009681075,0.000002324116,0.00004616255,0.00003983549,0.6744609,0.0002059792,0.002476042,0.00007654451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979888,0.00004369364,0.0001947476,0.00003025985,0.0003567752,0.0001534478,0.0002650692,0.00001198683,0.0009552315],"genre_scores_gemma":[0.9988461,0.00002401462,0.0005995943,0.0001261908,0.0001608807,0.00001081962,0.000006437079,0.000007108192,0.0002188494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.262997,"threshold_uncertainty_score":0.6938761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119991767344544,"score_gpt":0.2444047153976146,"score_spread":0.2324055386631602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}