{"id":"W2786537973","doi":"10.1126/science.aan0814","title":"<i>C1orf106</i> is a colitis risk gene that regulates stability of epithelial adherens junctions","year":2018,"lang":"en","type":"article","venue":"Science","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Canada Foundation for Innovation; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust; Crohn's and Colitis Foundation of America","keywords":"Adherens junction; Inflammatory bowel disease; Colitis; Ulcerative colitis; Tight junction; Gene; Inflammatory Bowel Diseases; Gastrointestinal tract; Inflammation; Cadherin; Biology; Immunology; Cancer research; Disease; Medicine; Cell biology; Genetics; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002112703,0.0009006891,0.0005155003,0.0004132934,0.0006773304,0.0006026613,0.0004486013,0.002218984,0.005710489],"category_scores_gemma":[0.0005338562,0.0001292747,0.0004641172,0.0003158757,0.0005926396,0.0002684009,0.0003107213,0.001556272,0.002408309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006181988,"about_ca_system_score_gemma":0.0002410654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001219412,"about_ca_topic_score_gemma":0.001159963,"domain_scores_codex":[0.9998074,0.00002185424,0.00001622528,0.00006734753,0.00005998978,0.00002723716],"domain_scores_gemma":[0.999692,0.0000934198,0.0001103395,0.00001385342,0.00003383683,0.0000566301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003204141,0.0001736849,0.02430242,0.001043124,0.0003271757,0.02794736,0.0002783118,0.001145689,0.3304128,0.01557726,0.3935383,0.2020498],"study_design_scores_gemma":[0.0003738432,0.0006230474,0.117494,0.0006653261,0.0004200908,0.07361393,0.0002171347,0.002335368,0.1572739,0.01089634,0.635911,0.0001760056],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5235549,0.1083923,0.0232837,0.1220819,0.044812,0.0003268226,0.01694997,0.003190367,0.1574081],"genre_scores_gemma":[0.8533415,0.03399703,0.008999099,0.01887033,0.01836941,0.0001478422,0.01119864,0.0004615523,0.05461454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005710489,"threshold_uncertainty_score":0.01910347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119991767344544,"score_gpt":0.2444047153976146,"score_spread":0.2324055386631602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}