{"id":"W2786632296","doi":"10.1016/s1474-4422(18)30032-2","title":"The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study","year":2018,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"TRIUMF; University of British Columbia, Okanagan Campus; University of British Columbia; Vancouver Coastal Health","funders":"Genentech; National Institute of Neurological Disorders and Stroke; TRIUMF","keywords":"Parkinson's disease; LRRK2; Acetylcholinesterase; Medicine; Progressive supranuclear palsy; Disease; Internal medicine; Cholinergic; Neurology; Pathology; Psychology; Oncology; Neuroscience; Psychiatry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006419027,0.0001407307,0.0003046363,0.00004986845,0.0002071314,0.00001649895,0.0001773616,0.00002793747,0.00001394041],"category_scores_gemma":[0.0001377442,0.0000621773,0.00005391787,0.0001107803,0.0003475492,0.00002050485,0.00006575222,0.0001672222,0.000009737359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001437957,"about_ca_system_score_gemma":0.00003203639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005888073,"about_ca_topic_score_gemma":0.00009514097,"domain_scores_codex":[0.9985492,0.000546432,0.0002324118,0.0002413245,0.0002225968,0.0002081009],"domain_scores_gemma":[0.998383,0.0008763997,0.0001536069,0.0004813954,0.00005108007,0.00005445662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003564813,0.0002097617,0.9939077,0.00007374574,0.0001051164,0.0001868472,0.0001064926,0.00003928418,0.000103005,0.001606853,0.00004805273,0.00004826514],"study_design_scores_gemma":[0.002748842,0.003085506,0.9926172,0.00002300922,0.0001230794,0.0001000326,0.00003810323,0.0004289513,0.0001552739,0.0001264032,0.0005124245,0.00004110147],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970732,0.0001825635,0.000001156702,0.001098211,0.0001810336,0.000985571,0.00007175764,0.00002221223,0.0003843131],"genre_scores_gemma":[0.9993208,0.00003366018,0.000001809968,0.000172152,0.0002111296,0.000172991,0.000006471161,0.00001432219,0.00006663257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002875745,"threshold_uncertainty_score":0.2535517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02196163873862441,"score_gpt":0.3090713972447238,"score_spread":0.2871097585060994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}