{"id":"W2786639886","doi":"10.1016/j.cmi.2018.01.030","title":"ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Immune checkpoint inhibitors, cell adhesion inhibitors, sphingosine-1-phosphate receptor modulators and proteasome inhibitors)","year":2018,"lang":"en","type":"review","venue":"Clinical Microbiology and Infection","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"Sphingosine-1-phosphate; Immune system; Perspective (graphical); Immunology; Medicine; Biology; Sphingosine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002163053,0.0007576877,0.002341144,0.0004689947,0.0006041957,0.00005104631,0.00009815959,0.001359339,0.00002708984],"category_scores_gemma":[0.001365754,0.0004602745,0.0005687879,0.0005193247,0.001996502,0.0001012436,0.0002203387,0.001352068,0.000006358838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002678268,"about_ca_system_score_gemma":0.0001903121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003546093,"about_ca_topic_score_gemma":0.00005337729,"domain_scores_codex":[0.9936571,0.002318801,0.002127167,0.001303896,0.0001037369,0.0004893534],"domain_scores_gemma":[0.9957241,0.002108832,0.001074456,0.000470089,0.0003210094,0.0003014812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02559176,0.08562441,0.5463125,0.02369053,0.01003332,0.00008028781,0.005617602,0.00001043734,0.03044361,0.002706939,0.002772353,0.2671163],"study_design_scores_gemma":[0.07552392,0.2176681,0.1931983,0.05860669,0.01330104,0.0009636024,0.004573098,0.0001001772,0.004393699,0.004821812,0.4200876,0.006761902],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.608571,0.3844838,0.000001792602,0.00007907486,0.0007688958,0.005854503,0.0001533206,0.00007522712,0.00001232676],"genre_scores_gemma":[0.5105178,0.4883332,0.00001569276,0.00004277545,0.0004051901,0.0003945951,0.0002330547,0.0000466463,0.00001105636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4173152,"threshold_uncertainty_score":0.9999371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03306650589934367,"score_gpt":0.3372703608189124,"score_spread":0.3042038549195687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}