{"id":"W2786732655","doi":"10.1158/1078-0432.ccr-18-2521","title":"Circulating Tumor DNA in HER2-Amplified Breast Cancer: A Translational Research Substudy of the NeoALTTO Phase III Trial","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Genentech; Fonds De La Recherche Scientifique - FNRS; National Breast Cancer Foundation; Breast Cancer Research Foundation; Pfizer; GlaxoSmithKline","keywords":"Digital polymerase chain reaction; Medicine; Circulating tumor DNA; Internal medicine; Breast cancer; Oncology; Nat; Neoadjuvant therapy; Cancer; Odds ratio; Gastroenterology; Polymerase chain reaction; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005440919,0.0001449645,0.0003750911,0.0001215746,0.0001624774,0.00004367008,0.0006931033,0.0001995963,0.000350478],"category_scores_gemma":[0.0006825339,0.0001186019,0.0002220061,0.0006503374,0.0005242922,0.000006307048,0.0003524448,0.0009497675,0.00001082808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001170057,"about_ca_system_score_gemma":0.002354702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003679973,"about_ca_topic_score_gemma":0.004212812,"domain_scores_codex":[0.9959908,0.0008857489,0.0008495937,0.0006882724,0.0009334016,0.0006521646],"domain_scores_gemma":[0.9975445,0.0007871065,0.0001371304,0.0007231548,0.0006427355,0.000165377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1541449,0.004871753,0.5065193,0.0003676088,0.0004092529,0.00004104565,0.0009377243,0.002460656,0.2636111,0.001530163,0.01020505,0.05490142],"study_design_scores_gemma":[0.3775938,0.007196934,0.5079653,0.001253028,0.00009558111,0.00003411443,0.001817913,0.003228171,0.0393636,0.003404836,0.05657125,0.001475511],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938366,0.001356623,0.000007074507,0.001652602,0.0006155523,0.001694012,0.0002648719,0.00000362067,0.0005690313],"genre_scores_gemma":[0.9971651,0.0009304959,0.0000169161,0.000149187,0.00105737,0.0003292063,0.0000255232,0.00003324333,0.0002929619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2242475,"threshold_uncertainty_score":0.5563042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1904980984934724,"score_gpt":0.5213238206696866,"score_spread":0.3308257221762143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}