{"id":"W2786732655","doi":"10.1158/1078-0432.ccr-18-2521","title":"Circulating Tumor DNA in HER2-Amplified Breast Cancer: A Translational Research Substudy of the NeoALTTO Phase III Trial","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Genentech; Fonds De La Recherche Scientifique - FNRS; National Breast Cancer Foundation; Breast Cancer Research Foundation; Pfizer; GlaxoSmithKline","keywords":"Digital polymerase chain reaction; Medicine; Circulating tumor DNA; Internal medicine; Breast cancer; Oncology; Nat; Neoadjuvant therapy; Cancer; Odds ratio; Gastroenterology; Polymerase chain reaction; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003026048,0.0006143856,0.0009977996,0.0001726909,0.0002358285,0.0007511668,0.0004618919,0.0005954538,0.001618354],"category_scores_gemma":[0.002054782,0.0001904763,0.0006905402,0.0002551767,0.0005121981,0.0006915919,0.0003782688,0.001100793,0.0004305368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004406905,"about_ca_system_score_gemma":0.0005721162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002514599,"about_ca_topic_score_gemma":0.001001272,"domain_scores_codex":[0.9991897,0.0005598703,0.0000372301,0.00009009276,0.00007743511,0.00004567604],"domain_scores_gemma":[0.9984286,0.0004747506,0.000497568,0.0002252737,0.0001189655,0.0002547248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8124403,0.009678202,0.0648408,0.001743875,0.004105854,0.0001747521,0.0002768282,0.001708964,0.02023291,0.000504598,0.006542501,0.07775037],"study_design_scores_gemma":[0.5381988,0.2080457,0.215854,0.0003883571,0.005862189,0.000953478,0.000250888,0.004492146,0.008239334,0.001506968,0.01610347,0.0001047157],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911987,0.00303948,0.0004464664,0.0005746175,0.00009284917,0.0006767072,0.001557058,0.00003649703,0.002377572],"genre_scores_gemma":[0.9882218,0.001442966,0.001224929,0.001142034,0.000254369,0.001876618,0.00421182,0.00002102298,0.001604491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003026048,"threshold_uncertainty_score":0.01600349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1904980984934724,"score_gpt":0.5213238206696866,"score_spread":0.3308257221762143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}