{"id":"W2786797148","doi":"10.1038/s41431-017-0089-8","title":"Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics","year":2018,"lang":"en","type":"article","venue":"European Journal of Human Genetics","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; University of British Columbia","funders":"Erasmus+; Fonds de Recherche du Québec - Santé; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; European Commission; Canadian Institutes of Health Research; Cancer Research Society; Université Laval","keywords":"COPD; Epigenetics; DNA methylation; Quantitative trait locus; Biology; Expression quantitative trait loci; Locus (genetics); Rotterdam Study; Genetics; Genome-wide association study; Genetic association; Population; Gene; Single-nucleotide polymorphism; Gene expression; Genotype; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004642635,0.0002005264,0.0003271907,0.0005427856,0.0001610582,0.0004926238,0.0003318362,0.0003607247,0.001037641],"category_scores_gemma":[0.000444745,0.0001803345,0.000357781,0.0005034104,0.0002964513,0.0004161538,0.000373685,0.000399404,0.0001739706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002806537,"about_ca_system_score_gemma":0.0003408697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002592843,"about_ca_topic_score_gemma":0.004242389,"domain_scores_codex":[0.9998686,0.00002343295,0.000006965002,0.00005355086,0.00002624929,0.00002125686],"domain_scores_gemma":[0.9998533,0.00004389281,0.00005213742,0.00001343441,0.0000219242,0.00001532196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000751779,0.00009712922,0.2911376,0.001098284,0.0007042254,0.0008525818,0.0009514313,0.004748971,0.5502822,0.005085818,0.002365192,0.1419248],"study_design_scores_gemma":[0.00003359027,0.0002277573,0.9542468,0.0002134638,0.0002707609,0.0005677346,0.0005710669,0.006555018,0.01482587,0.007355358,0.01509711,0.000035427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9291958,0.03659048,0.02383121,0.003465885,0.00009120919,0.00005940639,0.00313369,0.0001252307,0.003507112],"genre_scores_gemma":[0.9698482,0.0152633,0.01026687,0.001226358,0.0001002553,0.00007011656,0.001255304,0.00002349939,0.001946124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002592843,"threshold_uncertainty_score":0.005155563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06152940539291494,"score_gpt":0.2950564618707725,"score_spread":0.2335270564778576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}