{"id":"W2786854070","doi":"10.1016/j.stem.2018.01.011","title":"Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies","year":2018,"lang":"en","type":"review","venue":"Cell stem cell","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":450,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; Damon Runyon Cancer Research Foundation","keywords":"Biology; Haematopoiesis; Somatic evolution in cancer; Immunology; Cancer research; Evolutionary biology; Genetics; Stem cell; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005800578,0.0006975979,0.002277284,0.0004904158,0.0001721087,0.00007825139,0.0003869006,0.0006292547,0.0002802768],"category_scores_gemma":[0.00002811847,0.0005539983,0.0004751848,0.0006835545,0.0002210933,0.00006508551,0.0005087858,0.0006185266,0.003672936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001048731,"about_ca_system_score_gemma":0.0011163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002529002,"about_ca_topic_score_gemma":0.000002594883,"domain_scores_codex":[0.9964694,0.0001900723,0.0008313177,0.0009955526,0.0006943208,0.0008193864],"domain_scores_gemma":[0.9975441,0.0002760823,0.0002793115,0.0009872904,0.0002334506,0.000679743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001603544,0.0005888224,0.00009063014,0.5614768,0.0004174627,0.0009334694,0.001283368,2.764251e-7,0.000700621,0.0005271524,0.2730264,0.1607946],"study_design_scores_gemma":[0.0004335562,0.0003092533,0.000008991158,0.01061551,0.000875493,0.0005565261,0.0001819147,0.000005061538,0.0006778677,0.00001802274,0.985803,0.0005147794],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008112238,0.9796396,0.0001269592,0.00007942441,0.0002455034,0.001643814,0.00005156827,0.0001115806,0.01729026],"genre_scores_gemma":[0.0002187517,0.9443041,0.0009072449,0.0001181884,0.0005216412,0.0002452037,0.00007534459,0.000168707,0.05344078],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7127766,"threshold_uncertainty_score":0.9996911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03664998042485567,"score_gpt":0.3074273032066217,"score_spread":0.270777322781766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}