{"id":"W2787014069","doi":"10.1158/1535-7163.targ-17-b148","title":"Abstract B148: Activity of the TAM kinase-targeting compound, SLC-391, is mediated by the engagement of the immune system in CT-26 syngeneic mouse model","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"SignalChem (Canada)","funders":"","keywords":"Immune system; Cancer research; Tumor microenvironment; Kinase; CD8; Biology; Immunology; Cancer; Pharmacology; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005535774,0.0002119484,0.0003216429,0.0000373509,0.0002703267,0.00001186632,0.0006369374,0.000128152,0.00003120086],"category_scores_gemma":[0.00001450185,0.0001187454,0.0001946026,0.0002438604,0.0004377113,0.00004647331,0.0001844502,0.0003731935,0.000005852674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001698706,"about_ca_system_score_gemma":0.0001234427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006855062,"about_ca_topic_score_gemma":0.0000615181,"domain_scores_codex":[0.9983787,0.0005061373,0.0004634978,0.0002226777,0.0001365457,0.0002924553],"domain_scores_gemma":[0.9985695,0.00008552855,0.000501483,0.0007101531,0.000124393,0.00000897143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008140917,0.0001269546,0.0008185052,0.00004890548,0.0003550208,2.110274e-7,0.0008325894,0.0006759518,0.9945795,0.0001025348,0.00009751036,0.002280916],"study_design_scores_gemma":[0.0007778422,0.00003414342,0.006647857,0.0001029515,0.0001082847,0.000001711968,0.0002287002,0.002333802,0.9871966,0.00002272957,0.002417705,0.0001276896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826252,0.0153369,0.0002682399,0.0005747013,0.0004014879,0.0005396656,0.0001002076,0.00002107019,0.0001325551],"genre_scores_gemma":[0.9992474,0.0002213693,0.000009200913,0.0002962561,0.00001203907,0.0000419127,0.00001026558,0.00003389069,0.0001276484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01662225,"threshold_uncertainty_score":0.4842298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02416915970491095,"score_gpt":0.262548770211692,"score_spread":0.2383796105067811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}