{"id":"W2787024316","doi":"10.1128/jvi.00022-18","title":"NS1 Protein of 2009 Pandemic Influenza A Virus Inhibits Porcine NLRP3 Inflammasome-Mediated Interleukin-1 Beta Production by Suppressing ASC Ubiquitination","year":2018,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Inflammasome; Biology; Influenza A virus; Ubiquitin; Secretion; Innate immune system; Caspase 1; Proinflammatory cytokine; Cell biology; Virus; Virology; Immunology; Immune system; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006205572,0.0001864865,0.0003309262,0.000204059,0.00006895133,0.00001381527,0.000226127,0.0002983657,0.00004748273],"category_scores_gemma":[0.0004623579,0.0001668524,0.0001190174,0.0001509082,0.0002764383,0.00003857768,0.00009000294,0.0002708936,0.000009193566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002678674,"about_ca_system_score_gemma":0.0001356779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001107089,"about_ca_topic_score_gemma":0.00003240692,"domain_scores_codex":[0.9982971,0.000176983,0.0008327144,0.0002244496,0.0001902392,0.0002785435],"domain_scores_gemma":[0.9981402,0.00001365912,0.0009762492,0.0002321217,0.000577901,0.00005993143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009375225,0.0001127882,0.004994023,0.00002596759,0.000107312,0.000002695845,0.0002131216,0.00001888618,0.9887697,0.000005394459,0.002322134,0.00249043],"study_design_scores_gemma":[0.001489534,0.002360221,0.004598907,0.00006562246,0.00004379349,0.0001080613,0.00008787262,0.00001664961,0.9668931,0.00007533201,0.02410745,0.0001533949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970717,0.001546022,0.0002917705,0.0004113817,0.0002966625,0.0002148499,0.0000126305,0.000007431915,0.0001475968],"genre_scores_gemma":[0.9985484,0.0001803116,0.0001543607,0.0003170644,0.0005336381,0.000007438245,0.0000589639,0.00002429234,0.0001754738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02187656,"threshold_uncertainty_score":0.6804044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008316402430435861,"score_gpt":0.2573350715124598,"score_spread":0.249018669082024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}