{"id":"W2787024316","doi":"10.1128/jvi.00022-18","title":"NS1 Protein of 2009 Pandemic Influenza A Virus Inhibits Porcine NLRP3 Inflammasome-Mediated Interleukin-1 Beta Production by Suppressing ASC Ubiquitination","year":2018,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Inflammasome; Biology; Influenza A virus; Ubiquitin; Secretion; Innate immune system; Caspase 1; Proinflammatory cytokine; Cell biology; Virus; Virology; Immunology; Immune system; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070534,0.0003301637,0.0002375818,0.00009561684,0.000107031,0.0001613186,0.0001788275,0.0002472338,0.0008464604],"category_scores_gemma":[0.0001094696,0.00009890353,0.0002849743,0.00008690287,0.0001677055,0.0001391002,0.0001015527,0.0003590368,0.000293029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002112471,"about_ca_system_score_gemma":0.0001593012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004614686,"about_ca_topic_score_gemma":0.0004752883,"domain_scores_codex":[0.9999168,0.00001623222,0.0000127136,0.00001403982,0.0000165287,0.00002360248],"domain_scores_gemma":[0.9999357,0.00001549649,0.00001738519,0.000008121991,0.000006788157,0.00001639048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004021642,0.00006005302,0.0001666044,0.0000625736,0.000008034383,0.00003433905,0.000009255195,0.00007134921,0.9984275,0.00003400235,0.00003316844,0.0006909102],"study_design_scores_gemma":[0.00006696889,0.001151927,0.006752703,0.00001080041,0.00002330676,0.0002774407,0.00003245032,0.001431571,0.9887023,0.00003721158,0.001508037,0.00000535158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974539,0.001292176,0.0004322533,0.00004521274,0.00002547946,0.00001423587,0.0002058363,0.00001463614,0.0005163888],"genre_scores_gemma":[0.9968643,0.0006956264,0.0009124362,0.00005175422,0.00000992463,0.00002304227,0.0006671956,0.00000671399,0.0007688919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008464604,"threshold_uncertainty_score":0.002831638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008316402430435861,"score_gpt":0.2573350715124598,"score_spread":0.249018669082024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}