{"id":"W2787045767","doi":"10.1016/j.chembiol.2018.01.009","title":"Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action","year":2018,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Toronto; McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Johnson and Johnson","keywords":"Rifamycin; Monooxygenase; Antibiotics; Microbiology; Enzyme; Mechanism of action; Biology; Antibiotic resistance; Biochemistry; Chemistry; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001971647,0.000447211,0.0005133895,0.0001878936,0.0001827286,0.0008571237,0.0004039852,0.0007233488,0.0007263643],"category_scores_gemma":[0.0001753838,0.000164401,0.0002575463,0.0001068732,0.0004969962,0.0009716835,0.0004748984,0.0009068474,0.0009813968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003285335,"about_ca_system_score_gemma":0.0001715922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009929504,"about_ca_topic_score_gemma":0.0000992177,"domain_scores_codex":[0.9998523,0.00002094501,0.000007049879,0.00004745035,0.00004447704,0.00002782416],"domain_scores_gemma":[0.9999064,0.00001598006,0.00002296578,0.00001520237,0.00000983982,0.00002953649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000615239,0.00001703363,0.0001491588,0.00008557248,0.000005114946,0.0002210405,0.00002613395,0.0001478732,0.9859766,0.003687699,0.0003043861,0.009317836],"study_design_scores_gemma":[0.00001841768,0.0003555851,0.0008942352,0.00001284678,0.00001891537,0.003211509,0.00004073838,0.001048711,0.9583302,0.0009980657,0.03504988,0.00002091372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8172429,0.05043073,0.102401,0.003400913,0.0008039899,0.0001347698,0.0005468297,0.002012314,0.02302645],"genre_scores_gemma":[0.9165245,0.01623356,0.04698906,0.0005706168,0.0003029197,0.0001183366,0.0007003783,0.0001259745,0.01843447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008571237,"threshold_uncertainty_score":0.002429962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111183462289358,"score_gpt":0.256459158743897,"score_spread":0.2453408125149612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}