{"id":"W2787045767","doi":"10.1016/j.chembiol.2018.01.009","title":"Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action","year":2018,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Toronto; McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Johnson and Johnson","keywords":"Rifamycin; Monooxygenase; Antibiotics; Microbiology; Enzyme; Mechanism of action; Biology; Antibiotic resistance; Biochemistry; Chemistry; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013584,0.0001675111,0.0002055784,0.00002782713,0.00003822261,0.000006838976,0.0002607877,0.0003128091,0.00006747807],"category_scores_gemma":[0.00004015556,0.0001393477,0.00004678225,0.00009474385,0.0004212731,0.000004682458,0.00006583337,0.00008620828,0.00001274667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001756827,"about_ca_system_score_gemma":0.00005055854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001217904,"about_ca_topic_score_gemma":0.00007624343,"domain_scores_codex":[0.9989069,0.00007075298,0.0002274377,0.0004634381,0.0000661565,0.0002653784],"domain_scores_gemma":[0.9991387,0.00001421898,0.0001573633,0.0004571109,0.0001478517,0.00008479379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008699734,0.00008177372,0.0008275462,0.00002515208,0.00002243618,8.188317e-7,0.00001890289,1.060706e-7,0.9969478,0.0007322351,0.0003783754,0.00009491843],"study_design_scores_gemma":[0.0005075972,0.0006828291,0.0002238194,0.00001588087,0.00001605145,0.000005844483,0.0000519296,0.000009900561,0.9925463,0.0006001017,0.005165747,0.0001740625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919655,0.000100346,0.004467431,0.00004284306,0.0001096221,0.0001237164,0.00001764324,0.00001922589,0.003153727],"genre_scores_gemma":[0.9939801,0.00004297284,0.004768811,0.0001090511,0.0002831134,0.000005648068,0.0001737959,0.00002274678,0.0006138314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004787372,"threshold_uncertainty_score":0.5682433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111183462289358,"score_gpt":0.256459158743897,"score_spread":0.2453408125149612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}