{"id":"W2787084245","doi":"10.1021/acs.jmedchem.7b01178","title":"Glutathione <i>S</i>-Transferase π-Activatable <i>O</i><sup>2</sup>-(Sulfonylethyl Derived) Diazeniumdiolates Potently Suppress Melanoma in Vitro and in Vivo","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Kom op tegen Kanker; Program for New Century Excellent Talents in University; Government of Jiangsu Province; National Natural Science Foundation of China","keywords":"Chemistry; In vivo; In vitro; Glutathione; Transferase; Melanoma; Glutathione S-transferase; Enzyme; Biochemistry; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163573,0.0002935821,0.0001745101,0.0001209464,0.0000640443,0.00009657488,0.000161756,0.0001877122,0.000612707],"category_scores_gemma":[0.00008130746,0.0000838304,0.0001650865,0.0001397608,0.0001255303,0.0001057951,0.000083433,0.0002338846,0.000177254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001499796,"about_ca_system_score_gemma":0.0001880126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002413803,"about_ca_topic_score_gemma":0.0005711439,"domain_scores_codex":[0.9999474,0.0000158455,0.000004826603,0.00001111545,0.000008924688,0.00001194558],"domain_scores_gemma":[0.9999437,0.000005748436,0.00002298714,0.000004783429,0.000008258428,0.00001446006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001320474,0.00002380772,0.0002044537,0.00003041663,0.000004630193,0.00002443961,0.000007188325,0.00008983773,0.9977647,0.00008568045,0.00002423523,0.001608587],"study_design_scores_gemma":[0.00002794334,0.0008894728,0.0009197856,0.000002677079,0.00001292894,0.000108581,0.000008622348,0.0001564739,0.9957479,0.00003001281,0.002092849,0.00000294492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991619,0.001381065,0.005263152,0.00007358649,0.00002129538,0.00005715045,0.0002544854,0.00006223396,0.001268015],"genre_scores_gemma":[0.9886405,0.001236324,0.00718838,0.00005270979,0.000008327303,0.00004161388,0.0005618008,0.00001435382,0.002255964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000612707,"threshold_uncertainty_score":0.002049685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005710214562008304,"score_gpt":0.2212248215285105,"score_spread":0.2155146069665022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}