{"id":"W2787084245","doi":"10.1021/acs.jmedchem.7b01178","title":"Glutathione <i>S</i>-Transferase π-Activatable <i>O</i><sup>2</sup>-(Sulfonylethyl Derived) Diazeniumdiolates Potently Suppress Melanoma in Vitro and in Vivo","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Kom op tegen Kanker; Program for New Century Excellent Talents in University; Government of Jiangsu Province; National Natural Science Foundation of China","keywords":"Chemistry; In vivo; In vitro; Glutathione; Transferase; Melanoma; Glutathione S-transferase; Enzyme; Biochemistry; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005054608,0.0002938341,0.0004754195,0.00009619291,0.00006385738,0.00002609343,0.0002748776,0.0002850446,0.0001353465],"category_scores_gemma":[0.0001095507,0.0002596331,0.0001237801,0.0001724825,0.0002630849,0.00002126563,0.00005192773,0.0004992014,0.000001384278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003775832,"about_ca_system_score_gemma":0.0001684066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000706233,"about_ca_topic_score_gemma":0.0000136775,"domain_scores_codex":[0.9981398,0.00007558113,0.0006814218,0.0003356941,0.0003263899,0.0004410889],"domain_scores_gemma":[0.9991491,0.00005713752,0.0001446705,0.0002331774,0.0001408703,0.0002750022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002735481,0.0001546087,0.001705452,0.000098371,0.00005455092,0.0002910623,0.0003976783,0.00009807158,0.9935804,7.878325e-7,0.0003147293,0.0005687907],"study_design_scores_gemma":[0.003543418,0.0004458422,0.0008708891,0.0002002796,0.00004743324,0.001244835,0.0005778938,0.0001805037,0.9898928,0.00003151759,0.002697394,0.0002671724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946666,0.003781388,0.000263867,0.0006290944,0.0001029638,0.0001007514,0.00004399619,0.000005037543,0.0004062755],"genre_scores_gemma":[0.9972891,0.0009914928,0.0004164917,0.0003904752,0.0007589218,0.000005679366,0.00001968076,0.00003245243,0.00009566379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003687595,"threshold_uncertainty_score":0.9999856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005710214562008304,"score_gpt":0.2212248215285105,"score_spread":0.2155146069665022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}