{"id":"W2787120418","doi":"10.1021/acs.organomet.7b00915","title":"Iridium and Rhodium Complexes Containing Enantiopure Primary Amine-Tethered <i>N</i>-Heterocyclic Carbenes: Synthesis, Characterization, Reactivity, and Catalytic Asymmetric Hydrogenation of Ketones","year":2018,"lang":"en","type":"article","venue":"Organometallics","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; Canada Council for the Arts","keywords":"Chemistry; Enantiopure drug; Iridium; Medicinal chemistry; Reactivity (psychology); Carbene; Ligand (biochemistry); Hydride; Amine gas treating; Denticity; Bimetallic strip; Catalysis; Rhodium; Polymer chemistry; Organic chemistry; Enantioselective synthesis; Metal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001755295,0.0003413556,0.0001745976,0.000102534,0.00008920759,0.0002849105,0.0004102705,0.0002412089,0.000791107],"category_scores_gemma":[0.0001628755,0.0001741474,0.0001378709,0.0001089206,0.0001638067,0.0002198175,0.0001502824,0.0002755309,0.0003066898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002931215,"about_ca_system_score_gemma":0.0001075103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000734041,"about_ca_topic_score_gemma":0.001295462,"domain_scores_codex":[0.9998142,0.0000264846,0.00001301915,0.00003868532,0.0000409434,0.00006665776],"domain_scores_gemma":[0.9999006,0.00001251104,0.00002827208,0.00001532409,0.00001514566,0.00002813477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001300866,0.00002026376,0.0001048585,0.00004657543,0.000005266448,0.00005301918,0.00002297608,0.00009317898,0.9983005,0.0001121447,0.00005475845,0.001056487],"study_design_scores_gemma":[0.000008819063,0.0001142059,0.0005308687,0.00000255295,0.000005421813,0.00005783074,0.00001092769,0.0002384591,0.9984285,0.000007053037,0.0005912342,0.000004103037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929964,0.001053412,0.001707281,0.00003242904,0.00001311931,0.00002362131,0.0001567756,0.00007700184,0.003940009],"genre_scores_gemma":[0.9967499,0.000345877,0.001222079,0.00001094211,0.000002964423,0.00001093233,0.0001524847,0.00001479212,0.0014901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000791107,"threshold_uncertainty_score":0.002646506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147156944126027,"score_gpt":0.2216803016952366,"score_spread":0.2102087322539763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}