{"id":"W2787120418","doi":"10.1021/acs.organomet.7b00915","title":"Iridium and Rhodium Complexes Containing Enantiopure Primary Amine-Tethered <i>N</i>-Heterocyclic Carbenes: Synthesis, Characterization, Reactivity, and Catalytic Asymmetric Hydrogenation of Ketones","year":2018,"lang":"en","type":"article","venue":"Organometallics","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; Canada Council for the Arts","keywords":"Chemistry; Enantiopure drug; Iridium; Medicinal chemistry; Reactivity (psychology); Carbene; Ligand (biochemistry); Hydride; Amine gas treating; Denticity; Bimetallic strip; Catalysis; Rhodium; Polymer chemistry; Organic chemistry; Enantioselective synthesis; Metal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000280548,0.0003111561,0.0005851228,0.0005382644,0.0001963917,0.00008275054,0.0002210673,0.0001948509,0.0001099737],"category_scores_gemma":[0.0004249991,0.0003053131,0.00008761088,0.001173299,0.0003152962,0.0004352355,0.0001772983,0.0001307795,0.00001179941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008699814,"about_ca_system_score_gemma":0.00005004034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000814169,"about_ca_topic_score_gemma":0.00002031377,"domain_scores_codex":[0.9981849,0.00005361947,0.0005606172,0.0005154532,0.0003926335,0.0002927938],"domain_scores_gemma":[0.9983605,0.0003161598,0.0005115224,0.0004122449,0.0002486254,0.0001509412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000414789,0.0001524688,0.016254,0.0003009308,0.0002409546,0.000003133988,0.0004177103,5.407222e-7,0.9497239,0.0002045177,0.00001025133,0.0326501],"study_design_scores_gemma":[0.0006097822,0.00005791502,0.02574798,0.00005849327,0.0003287993,0.00005388659,0.0002643924,0.000639579,0.9676811,0.0000591869,0.004080771,0.000418132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939028,0.0005826611,0.0006569335,0.0002020246,0.00005897677,0.000132684,0.000139759,0.00009086417,0.004233307],"genre_scores_gemma":[0.9981651,0.0005141596,0.0001740995,0.0001000368,0.0001473895,0.00002190648,0.0004888503,0.00005811909,0.0003303678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03223197,"threshold_uncertainty_score":0.9999399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147156944126027,"score_gpt":0.2216803016952366,"score_spread":0.2102087322539763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}