{"id":"W2787139962","doi":"10.1101/234229","title":"Premarin has opposing effects on spatial learning, neural activiation and serum cytokine levels in middle age dependent on reproductive history","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Alzheimer Society","keywords":"Neurogenesis; Hippocampal formation; Menopause; Ovariectomized rat; Medicine; Hippocampus; Endocrinology; Internal medicine; Estrogen; Hormone; Morris water navigation task; Physiology; Psychology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001208333,0.0002045723,0.0002538213,0.0002457706,0.000142619,0.0002050569,0.00009150691,0.0001983307,0.001584222],"category_scores_gemma":[0.0001561149,0.0001371481,0.0002010226,0.0001008846,0.0002447746,0.0001475196,0.0001767879,0.0003579173,0.0001605138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001365464,"about_ca_system_score_gemma":0.0001634487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000531632,"about_ca_topic_score_gemma":0.0009547112,"domain_scores_codex":[0.9999412,0.000007420743,0.000004388216,0.0000156706,0.00001040091,0.00002085996],"domain_scores_gemma":[0.9999032,0.00000923775,0.00003099795,0.00001101459,0.000007929495,0.00003758365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01165759,0.000589307,0.0214442,0.0001330281,0.0000717593,0.0003231706,0.0001959157,0.00004080374,0.9513194,0.0001627333,0.0003189459,0.01374309],"study_design_scores_gemma":[0.0003001136,0.009796762,0.7222626,0.00003622473,0.0002287568,0.0007129406,0.0005157971,0.0003974706,0.2600407,0.000497152,0.005183794,0.00002766681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972174,0.001660794,0.0002346123,0.0001031065,0.00003009864,0.00000900881,0.0002673654,0.00001155453,0.0004660457],"genre_scores_gemma":[0.9963942,0.000927271,0.0002916474,0.0001176457,0.00002536903,0.00003808712,0.0002677063,0.000005683346,0.001932323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001584222,"threshold_uncertainty_score":0.005299807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06518186555056966,"score_gpt":0.2794536125524031,"score_spread":0.2142717470018334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}