{"id":"W2787203161","doi":"10.1021/acs.orglett.8b00153","title":"Rhodium-Catalyzed Asymmetric Conjugate Alkynylation/Aldol Cyclization Cascade for the Formation of α-Propargyl-β-hydroxyketones","year":2018,"lang":"en","type":"article","venue":"Organic Letters","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto; Alphora Research","keywords":"Chemistry; Aldol reaction; Propargyl; Stereocenter; Alkynylation; Conjugate; Rhodium; Moiety; Catalysis; Cascade; Stereochemistry; Enantioselective synthesis; Medicinal chemistry; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005552841,0.0002003696,0.0002298644,0.0001669175,0.0002887913,0.0000566258,0.000303318,0.0001188997,0.001009512],"category_scores_gemma":[0.0009937142,0.0001661362,0.0001193175,0.0007789622,0.0001977191,0.0003456211,0.00006616849,0.0001041465,0.00007736675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001719712,"about_ca_system_score_gemma":0.00007115112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003972179,"about_ca_topic_score_gemma":0.00002118445,"domain_scores_codex":[0.9984293,0.00004500297,0.0005876672,0.0002981099,0.0003851772,0.0002547428],"domain_scores_gemma":[0.9979283,0.0007087406,0.0004711229,0.0005177556,0.0003170187,0.00005707187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007069228,0.00003229479,0.0003094016,0.0001342922,0.00007194921,3.621697e-7,0.0005241617,0.0001667935,0.990327,0.000531373,0.005473265,0.002358418],"study_design_scores_gemma":[0.001147967,0.00001714274,0.0004968785,0.00002785128,0.0001546029,0.00002685329,0.0001296982,0.02150831,0.9681052,0.0002028809,0.00796805,0.0002145446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2758608,0.0001075189,0.7183404,0.003810476,0.0005740938,0.0004495049,0.00006773875,0.0001398203,0.0006497189],"genre_scores_gemma":[0.9943803,0.00002705977,0.00280771,0.00102235,0.0007831225,0.00007138513,0.0004890788,0.00006170796,0.0003572838],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7185196,"threshold_uncertainty_score":0.9999037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042656370752198,"score_gpt":0.2670679384964467,"score_spread":0.2466413747889247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}