{"id":"W2787203782","doi":"10.1016/j.ccell.2018.01.002","title":"Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma","year":2018,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Deutschen Konsortium für Translationale Krebsforschung; Wilhelm Sander-Stiftung; Deutsche Forschungsgemeinschaft; H2020 European Research Council; Howard Hughes Medical Institute","keywords":"Senescence; Melanoma; Biology; Cellular senescence; Cell biology; Cancer research; Genetics; Computational biology; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002857505,0.0001822427,0.0001934178,0.0001622055,0.0001710335,0.0002499262,0.0002217115,0.0002454385,0.001072285],"category_scores_gemma":[0.0001540583,0.0001346178,0.0002082362,0.0001161132,0.0001648537,0.0001871459,0.0002670504,0.0004780851,0.000216994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003095976,"about_ca_system_score_gemma":0.0002134072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003757111,"about_ca_topic_score_gemma":0.001616037,"domain_scores_codex":[0.999912,0.00001406558,0.000006592655,0.00002012773,0.00002377732,0.00002345595],"domain_scores_gemma":[0.9999409,0.000008099539,0.00001479411,0.00001266229,0.000008288878,0.0000151995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001174773,0.00002770918,0.0002335938,0.00002657052,0.000009376269,0.00002601404,0.000009477877,0.0001513446,0.9952782,0.0002901609,0.00003916389,0.003790856],"study_design_scores_gemma":[0.00003617821,0.0003800927,0.002602482,0.00000350043,0.00002401994,0.0001914711,0.00002566655,0.0009943184,0.9922796,0.0002090274,0.003249433,0.000004249503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896212,0.003447857,0.004641055,0.0002091386,0.00003728497,0.00003497208,0.00007385894,0.00006459601,0.001870111],"genre_scores_gemma":[0.9967743,0.0007727824,0.001207573,0.00003485438,0.000005753718,0.000009712609,0.00003983206,0.000007447256,0.001147836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001072285,"threshold_uncertainty_score":0.003587186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289963321680859,"score_gpt":0.272203947468506,"score_spread":0.2593043142516974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}