{"id":"W2787317683","doi":"10.2147/ijnrd.s136359","title":"Is the light at the end of the tunnel nigh? A review of ADPKD focusing on the burden of disease and tolvaptan as a new treatment","year":2018,"lang":"en","type":"review","venue":"International Journal of Nephrology and Renovascular Disease","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tolvaptan; Medicine; Disease; Intensive care medicine; Internal medicine; Heart failure","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003684369,0.0002708976,0.0005919904,0.0000520281,0.0001098671,0.00001332518,0.0006933674,0.000106042,0.0001176965],"category_scores_gemma":[0.0004431563,0.0001035086,0.001095759,0.00007880669,0.0006969065,0.000004553709,0.0002931586,0.000126185,0.000001494348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002476629,"about_ca_system_score_gemma":0.001036541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002802787,"about_ca_topic_score_gemma":0.000004187046,"domain_scores_codex":[0.998094,0.0004491996,0.0006641324,0.0002408827,0.0004198304,0.0001320174],"domain_scores_gemma":[0.9977688,0.000120843,0.0009853947,0.0006017666,0.0003040955,0.0002190903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01055194,0.002830434,0.0007669303,0.03712356,0.07679669,0.0003557193,0.002247054,0.00007368731,0.005713395,0.002561296,0.2600166,0.6009626],"study_design_scores_gemma":[0.000586117,0.0003538897,0.0004238211,0.009615478,0.004776053,0.0001435714,0.00002953804,0.000002298932,0.0002915827,0.000495929,0.9831572,0.0001245533],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01455929,0.9695522,0.000007200215,0.01493956,0.0001786513,0.0005017077,0.0001988148,7.65127e-7,0.00006176479],"genre_scores_gemma":[0.01594544,0.9810753,0.000008531199,0.001998914,0.0006080506,0.00001514394,0.00002781831,0.00001758943,0.0003031735],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7231405,"threshold_uncertainty_score":0.4220958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01891358501291486,"score_gpt":0.2959919652120414,"score_spread":0.2770783801991266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}