{"id":"W2787437964","doi":"10.7554/elife.31515","title":"Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate","year":2018,"lang":"en","type":"article","venue":"eLife","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw","keywords":"Wnt signaling pathway; Zebrafish; Transcriptome; Biology; Embryonic heart; Heart development; Cell biology; Embryonic stem cell; Computational biology; Signal transduction; Gene; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645717,0.0002528953,0.000230687,0.0003613344,0.000241579,0.000341195,0.0001272177,0.0002121552,0.001201465],"category_scores_gemma":[0.0002002083,0.0001880203,0.000323541,0.00031239,0.0001822764,0.0001674012,0.0002286509,0.0003482435,0.0004205804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002568715,"about_ca_system_score_gemma":0.0003193266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002306367,"about_ca_topic_score_gemma":0.008603065,"domain_scores_codex":[0.9998411,0.000007135567,0.000008808511,0.0000765681,0.00004402097,0.00002233782],"domain_scores_gemma":[0.9999208,0.00002321888,0.00002075031,0.000009482722,0.00001375301,0.00001203227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004260425,0.000004659086,0.002748612,0.00004974499,0.00001288873,0.00006435725,0.00002951707,0.000277172,0.9915976,0.0001533528,0.0001510606,0.004868487],"study_design_scores_gemma":[0.00002780251,0.0001072574,0.3188482,0.00004906327,0.0001067476,0.000582626,0.0001699284,0.008884987,0.6526669,0.0007211421,0.01780871,0.00002655346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454114,0.001663225,0.03102169,0.0002025839,0.00005401333,0.00003575661,0.01781901,0.0004668737,0.003325449],"genre_scores_gemma":[0.9218226,0.001756946,0.04247882,0.0002484908,0.00001857226,0.00008148519,0.0274145,0.0002592245,0.005919276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002306367,"threshold_uncertainty_score":0.004585862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715951188629646,"score_gpt":0.283722367981409,"score_spread":0.2665628560951125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}