{"id":"W2787504356","doi":"10.1098/rsob.170216","title":"Rett syndrome: a neurological disorder with metabolic components","year":2018,"lang":"en","type":"review","venue":"Open Biology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":216,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"National Institute of General Medical Sciences; Rett Syndrome Research Trust","keywords":"Rett syndrome; MECP2; Biology; Neuroscience; Neurological disorder; Phenotype; Bioinformatics; Neurodevelopmental disorder; Gene; Genetics; Central nervous system disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002626715,0.0007436005,0.0007739703,0.002025458,0.0003378725,0.0006403811,0.0005946196,0.000917078,0.002614787],"category_scores_gemma":[0.0006072547,0.0001479954,0.0003401427,0.001606637,0.0004547574,0.0008174147,0.0006558554,0.001422971,0.00163355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005826273,"about_ca_system_score_gemma":0.000894943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001374607,"about_ca_topic_score_gemma":0.002181842,"domain_scores_codex":[0.9998629,0.00001671659,0.00002753514,0.00002709786,0.00004925053,0.00001644155],"domain_scores_gemma":[0.9998292,0.00006758262,0.00003203115,0.000005914744,0.00004124519,0.00002396452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005672932,0.00002860716,0.0004693659,0.007718187,0.00007721731,0.001680951,0.00009252248,0.0002345139,0.002058991,0.004288049,0.05258291,0.9307119],"study_design_scores_gemma":[0.000009455335,0.00003242484,0.001004682,0.002113169,0.00007909837,0.0154994,0.00006025538,0.00004607471,0.0005072164,0.00188086,0.9787507,0.00001675975],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002186446,0.9970267,0.0002175871,0.0005933161,0.0002967487,0.000003580313,0.00003139118,0.00001900376,0.001593022],"genre_scores_gemma":[0.001832142,0.995715,0.0003434906,0.0004333606,0.0003093573,0.000005642404,0.00007951358,0.000003934633,0.00127752],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002614787,"threshold_uncertainty_score":0.008747339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04311033117153117,"score_gpt":0.3182430970511521,"score_spread":0.2751327658796209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}