{"id":"W2787519262","doi":"10.1038/nature25478","title":"MEK drives BRAF activation through allosteric control of KSR proteins","year":2018,"lang":"en","type":"article","venue":"Nature","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Kinase; Allosteric regulation; Cell biology; Protein kinase domain; Chemistry; Protein kinase A; MAPK/ERK pathway; Scaffold protein; c-Raf; Mitogen-activated protein kinase kinase; Biochemistry; Biology; Enzyme; Signal transduction; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004870965,0.00008683716,0.00009827236,0.00001471683,0.00003681975,0.000006149257,0.0001151413,0.0006137269,0.00003040513],"category_scores_gemma":[0.00007298194,0.00007187116,0.00004881621,0.00005421185,0.00006422722,0.000004762877,0.00003247181,0.000182828,0.000005796381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004134623,"about_ca_system_score_gemma":0.00003768763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005431863,"about_ca_topic_score_gemma":0.00001166818,"domain_scores_codex":[0.9994828,0.00002922725,0.00009924501,0.0001782268,0.00009502193,0.0001155422],"domain_scores_gemma":[0.9995617,0.000005894029,0.00007807413,0.0002122961,0.0001184505,0.00002362495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009977013,0.00003165314,0.0004024058,0.00001557177,0.00003204486,6.185621e-7,0.00008990266,5.386836e-7,0.9949773,0.0005827898,0.002821585,0.0009458163],"study_design_scores_gemma":[0.0005267153,0.0004654875,0.002363991,0.00001349001,0.000008715295,0.000003869497,0.00002328746,0.000009057259,0.9109151,0.0002435432,0.08534401,0.00008276213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985611,0.0003969335,0.006564535,0.0003423341,0.000209623,0.0002813544,0.00002626787,0.00001160388,0.0065563],"genre_scores_gemma":[0.9967921,0.00001514741,0.001277962,0.0009007238,0.000480324,0.00001313775,0.00006013149,0.00001079552,0.0004496126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08406223,"threshold_uncertainty_score":0.4733624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006254970096759588,"score_gpt":0.2442489508181233,"score_spread":0.2379939807213637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}