{"id":"W2787560446","doi":"10.1053/j.gastro.2018.02.016","title":"Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn’s Disease","year":2018,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Dalhousie University; Hospital for Sick Children; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; College of Dentistry, University of Kentucky; Crohn's and Colitis Foundation","keywords":"Chronic granulomatous disease; NADPH oxidase; Reactive oxygen species; Biology; Missense mutation; Immunology; Gene; Mutation; Molecular biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001844168,0.0001852103,0.0003724562,0.0001957167,0.0001105578,0.000003792854,0.0001411905,0.0001151315,0.00005979931],"category_scores_gemma":[0.0000572238,0.0001481643,0.00004650872,0.00009708677,0.0007811831,0.00009837732,0.0002348332,0.0002595633,0.00004789046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002199129,"about_ca_system_score_gemma":0.00003068176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008403629,"about_ca_topic_score_gemma":0.00006332657,"domain_scores_codex":[0.9984178,0.0003202301,0.0004108826,0.0004715205,0.00003530009,0.0003442439],"domain_scores_gemma":[0.9993082,0.00004339904,0.0002212511,0.0002416257,0.000141127,0.00004442966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005510029,0.0003531041,0.9830325,0.0000132061,0.00006951146,0.00001157625,0.000194111,0.000002083491,0.01030738,0.00008768133,0.0001198151,0.0002989764],"study_design_scores_gemma":[0.002546407,0.002129385,0.9935796,0.0000140662,0.00008268904,0.000008920772,0.0000408478,9.092822e-7,0.001246689,0.0001545735,0.0001099342,0.000085971],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984971,0.0001309417,0.0000409567,0.0002134475,0.0006779887,0.0003561717,0.00003943553,0.00001872919,0.00002521381],"genre_scores_gemma":[0.9992467,0.0001118295,0.0001121247,0.0001430385,0.0001431695,0.00001837863,0.00008970555,0.00001719355,0.0001179028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01054708,"threshold_uncertainty_score":0.6041966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100480763139259,"score_gpt":0.2234390658116687,"score_spread":0.2124342581802761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}