{"id":"W2787601395","doi":"10.1016/j.celrep.2018.01.018","title":"Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health; Cancer Prevention and Research Institute of Texas","keywords":"Sonic hedgehog; Medulloblastoma; Progenitor cell; Biology; Hedgehog signaling pathway; Patched; Progenitor; Cell biology; Carcinogenesis; Smoothened; Neural tube; Neural stem cell; Hedgehog; Cancer research; Stem cell; Signal transduction; Genetics; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288829,0.0002640195,0.0002469391,0.0002698663,0.0001339643,0.0003045549,0.0001966647,0.0002061412,0.0006244123],"category_scores_gemma":[0.0001195114,0.000175128,0.0002131424,0.0001441073,0.0003304034,0.0002296387,0.0003310412,0.0004773497,0.0004321045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002572023,"about_ca_system_score_gemma":0.0001998655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006003973,"about_ca_topic_score_gemma":0.0007197219,"domain_scores_codex":[0.9998353,0.00002296644,0.00001841121,0.00003920728,0.0000381299,0.00004602942],"domain_scores_gemma":[0.9998962,0.00001135405,0.00003568525,0.00001940355,0.000008219388,0.00002925554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000453521,0.00000616121,0.0003033144,0.000008891497,0.000001792648,0.00002493018,0.000009174277,0.0000243161,0.9991391,0.00005375504,0.000007903533,0.0003753113],"study_design_scores_gemma":[0.000008119636,0.0001521543,0.006364555,0.000003109108,0.00001517483,0.0003332921,0.00003370185,0.000392014,0.9913692,0.00004974008,0.001276631,0.000002416573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997099,0.0005518758,0.001531141,0.00002882312,0.000008061682,0.000008557434,0.0001655156,0.00004849171,0.0005585132],"genre_scores_gemma":[0.9975554,0.0005060255,0.000871519,0.00001241773,0.00000221429,0.00001039785,0.0002523467,0.00001662272,0.0007729777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006244123,"threshold_uncertainty_score":0.002088904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008097907910618839,"score_gpt":0.2149562614250441,"score_spread":0.2068583535144253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}