{"id":"W2787634639","doi":"10.1101/252056","title":"Loss of PRMT5 promotes PDGFRα degradation during oligodendrocyte differentiation and myelination","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Health Canada; Compute Canada","keywords":"Protein arginine methyltransferase 5; Cell biology; Oligodendrocyte; Platelet-derived growth factor receptor; Signal transduction; Neurodegeneration; Chemistry; Receptor; Arginine; Growth factor; Biology; Neuroscience; Cancer research; Central nervous system; Methylation; Methyltransferase; Biochemistry; Myelin; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363164,0.000199036,0.0001807609,0.000125487,0.0001372148,0.0002672926,0.0001757029,0.0002153948,0.001546605],"category_scores_gemma":[0.0001116351,0.00009303745,0.0002066219,0.00009063595,0.0002206794,0.0001659905,0.0002081129,0.0005301511,0.0005517314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003350357,"about_ca_system_score_gemma":0.0002156679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009350316,"about_ca_topic_score_gemma":0.0008723289,"domain_scores_codex":[0.9998492,0.00001778795,0.00001705001,0.00003461091,0.00004453072,0.00003674509],"domain_scores_gemma":[0.9999251,0.000006805301,0.00002776318,0.000009896339,0.000007959011,0.000022455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000146064,0.00001203712,0.0002601453,0.00002522914,0.000004426005,0.0000474999,0.00000977503,0.00006556304,0.9982158,0.0001677267,0.00006480971,0.0009810752],"study_design_scores_gemma":[0.000006612759,0.00005667826,0.001796347,0.000002675754,0.00000541799,0.0001177582,0.00001088518,0.0005083638,0.9956174,0.00003735149,0.001838781,0.000001589658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921515,0.001823215,0.003648717,0.0001832255,0.00004519394,0.000009360577,0.0004069607,0.00009949645,0.001632307],"genre_scores_gemma":[0.9940457,0.0003583302,0.001326028,0.00004589226,0.000006741907,0.000007300913,0.0004158388,0.00002434699,0.00376985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001546605,"threshold_uncertainty_score":0.005173862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00708307793024042,"score_gpt":0.2112711182919877,"score_spread":0.2041880403617473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}