{"id":"W2787702713","doi":"10.1007/s00401-018-1810-6","title":"The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033","year":2018,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; National Human Genome Research Institute; Swiss Bridge Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Temozolomide; Isocitrate dehydrogenase; O-6-methylguanine-DNA methyltransferase; Glioma; DNA methylation; Oncology; Internal medicine; Gene; Biology; Methyltransferase; Oligodendroglioma; Methylation; Medicine; Cancer research; Genetics; Astrocytoma; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000156357,0.0001177687,0.0003575732,0.0002708412,0.00009493807,0.0001709588,0.0001009409,0.0001864991,0.0004180616],"category_scores_gemma":[0.0003085886,0.000100923,0.0001836634,0.0002715036,0.0001368842,0.00007409559,0.0001063313,0.0001958645,0.00006676076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003310567,"about_ca_system_score_gemma":0.0001518706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002614307,"about_ca_topic_score_gemma":0.003914078,"domain_scores_codex":[0.9999263,0.00002190908,0.000005725805,0.00001676844,0.00001105112,0.00001813782],"domain_scores_gemma":[0.9998887,0.00003147177,0.00003828589,0.000008349374,0.000007875171,0.00002540198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0301017,0.0006047813,0.8532223,0.0001114879,0.0002578103,0.000382967,0.0002486816,0.0018453,0.08293051,0.00007284422,0.0004382984,0.02978335],"study_design_scores_gemma":[0.000321373,0.003753169,0.988802,0.000006422592,0.0001322858,0.0003549923,0.00007072965,0.001567952,0.004419632,0.0000627788,0.0005017916,0.000007012119],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997543,0.00009568503,0.00001931132,0.000008963647,5.33164e-7,0.000003515468,0.00007782225,0.000001402368,0.00003865059],"genre_scores_gemma":[0.9995611,0.00005187553,0.00005637967,0.00001901634,0.000001352931,0.000005407353,0.0002477363,0.000001185102,0.00005595997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002614307,"threshold_uncertainty_score":0.005198181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02780835521449571,"score_gpt":0.2783662866764832,"score_spread":0.2505579314619875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}