{"id":"W2787785723","doi":"10.1101/234294","title":"Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; McMaster University; Baycrest Hospital; St. Joseph’s Healthcare Hamilton","funders":"European Regional Development Fund; Instituto de Salud Carlos III; Tartu Ülikool; Academy of Finland; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Vrije Universiteit Amsterdam; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institutes of Health; Generalitat de Catalunya; European Commission; National Alliance for Research on Schizophrenia and Depression","keywords":"Genome-wide association study; Cannabis; Schizophrenia (object-oriented programming); Single-nucleotide polymorphism; Genetic association; Genetics; Psychiatry; Biology; Medicine; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001116044,0.0004271262,0.0006198266,0.001250153,0.0008649913,0.0006851776,0.0004419149,0.0005625876,0.004539166],"category_scores_gemma":[0.002390351,0.0003560861,0.001124883,0.00247182,0.0003583169,0.0002486989,0.0006213958,0.0006019472,0.000372036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003669542,"about_ca_system_score_gemma":0.0006627729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009983712,"about_ca_topic_score_gemma":0.02273776,"domain_scores_codex":[0.9993166,0.000128058,0.00007019156,0.0002598388,0.0001283313,0.00009712845],"domain_scores_gemma":[0.9988475,0.0004496213,0.0002881572,0.0001923972,0.00008106016,0.000141178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001613076,0.00007691819,0.9608845,0.0001874547,0.003584013,0.0008867885,0.0002261325,0.0002659432,0.013908,0.0001881467,0.001788842,0.01639022],"study_design_scores_gemma":[0.0001104293,0.0001008488,0.9944945,0.00002062662,0.001359596,0.0005774486,0.0000808694,0.0004180554,0.0009020429,0.0001513512,0.001771879,0.00001231924],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883818,0.002562057,0.001523715,0.0002727968,0.00002678987,0.00001660286,0.006538151,0.00005200563,0.0006261526],"genre_scores_gemma":[0.9923275,0.0007934823,0.002340246,0.0000691001,0.00003382137,0.00002354147,0.003595279,0.00002639621,0.0007906021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009983712,"threshold_uncertainty_score":0.01985121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015095919542679,"score_gpt":0.2440128219228546,"score_spread":0.2338618627274278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}