{"id":"W2787823540","doi":"10.1038/s41598-018-19688-1","title":"Development and characterisation of a panel of phosphatidylinositide 3-kinase – mammalian target of rapamycin inhibitor resistant lung cancer cell lines","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Irish Cancer Society","keywords":"PI3K/AKT/mTOR pathway; microRNA; Cancer research; Cell culture; Epithelial–mesenchymal transition; Biology; Mechanistic target of rapamycin; Cell growth; Chemistry; Cell biology; Signal transduction; Downregulation and upregulation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006909098,0.0004643642,0.0007385686,0.0008875242,0.0003818657,0.0008067057,0.0005311499,0.0005404405,0.001549556],"category_scores_gemma":[0.0005532198,0.0003336631,0.0005279042,0.001095332,0.0002285165,0.0002463714,0.0003373723,0.0009431779,0.002363579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002671354,"about_ca_system_score_gemma":0.0003848643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001831596,"about_ca_topic_score_gemma":0.002964314,"domain_scores_codex":[0.999124,0.0001024977,0.000155212,0.0001627955,0.0003619154,0.00009356746],"domain_scores_gemma":[0.999496,0.00008084026,0.00005170896,0.0001157661,0.0002063858,0.00004930039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001315369,0.0001528946,0.00147897,0.00008761046,0.00002110428,0.0002115329,0.0001692746,0.0003695436,0.9907168,0.0002540226,0.0007544072,0.005652211],"study_design_scores_gemma":[0.00007445178,0.001459896,0.02297684,0.00003805349,0.0001506909,0.002108759,0.0002896149,0.005087669,0.9376336,0.0001847182,0.02994812,0.00004759496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8877775,0.004237238,0.0597502,0.0009642311,0.000234832,0.003065319,0.03031692,0.0009373932,0.01271637],"genre_scores_gemma":[0.7715141,0.006606359,0.1111442,0.0007534596,0.00007973028,0.004817524,0.07962704,0.0003923665,0.02506537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001831596,"threshold_uncertainty_score":0.005183756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326739652654671,"score_gpt":0.2536338037921526,"score_spread":0.2403664072656059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}