{"id":"W2787929656","doi":"10.1007/s10549-018-4713-2","title":"Patient-reported predictors of early treatment discontinuation: treatment-related symptoms and health-related quality of life among postmenopausal women with primary breast cancer randomized to anastrozole or exemestane on NCIC Clinical Trials Group (CCTG) MA.27 (E1Z03)","year":2018,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Cancer Institute; Canadian Cancer Society Research Institute","keywords":"Anastrozole; Medicine; Exemestane; Aromatase inhibitor; Internal medicine; Breast cancer; Hazard ratio; Discontinuation; Quality of life (healthcare); Randomized controlled trial; Clinical endpoint; Oncology; Gynecology; Cancer; Physical therapy; Tamoxifen; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006893224,0.0001841171,0.0005640838,0.0001740278,0.0001646035,0.0003669254,0.0002276978,0.0006465443,0.002168446],"category_scores_gemma":[0.001862501,0.000188202,0.0008537532,0.0003134942,0.000125981,0.0002360527,0.0001946245,0.0008094682,0.0001489316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002801034,"about_ca_system_score_gemma":0.0003554227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002710873,"about_ca_topic_score_gemma":0.004511189,"domain_scores_codex":[0.9996974,0.0001151843,0.00003125323,0.00004549531,0.00005126852,0.00005942762],"domain_scores_gemma":[0.9992456,0.0002107722,0.0003090853,0.00003084279,0.00003411805,0.000169542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1030354,0.001592956,0.8655026,0.0001902106,0.001945971,0.00009780267,0.00009225551,0.0004655021,0.001471275,0.00005918125,0.001652031,0.02389479],"study_design_scores_gemma":[0.004391262,0.004920656,0.9887019,0.00002804941,0.000661785,0.00008454476,0.0000450595,0.0005200348,0.0001498927,0.00005543777,0.0004297089,0.00001163136],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977753,0.0009624663,0.00002844999,0.0001617021,0.00001826758,0.00002700803,0.0006956776,0.000003497898,0.0003275674],"genre_scores_gemma":[0.9987587,0.000196257,0.00003381582,0.00008930275,0.00002789405,0.00003075804,0.0005518222,8.661184e-7,0.0003106775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002710873,"threshold_uncertainty_score":0.007254183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05822184799215232,"score_gpt":0.3983368100951973,"score_spread":0.340114962103045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}