{"id":"W2787958089","doi":"10.1016/j.celrep.2018.01.070","title":"Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Turun Yliopistollinen Keskussairaala; Varsinais-Suomen Sairaanhoitopiiri; Biocenter Finland; Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg; Sigrid Juséliuksen Säätiö; Turun Yliopisto; Sweden-Japan Foundation; Gemeinnützige Hertie-Stiftung; Tekes; Biogen; California Department of Fish and Game; Else Kröner-Fresenius-Stiftung; Juvenile Diabetes Research Foundation Australia; European Commission; Åbo Akademi; Juvenile Diabetes Research Foundation United Kingdom; Juvenile Diabetes Research Foundation International; American Osteopathic Foundation; BC Children’s Hospital Foundation; Bundesministerium für Bildung und Forschung; Paulon Säätiö; Canadian Institute of Mining, Metallurgy and Petroleum; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Academy of Finland","keywords":"Effector; FOXP3; Biology; Immune system; Transcription factor; Repressor; In vitro; Cell biology; Downregulation and upregulation; Transcriptional regulation; Gene; Regulation of gene expression; Function (biology); Cancer research; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005583,0.0002508828,0.0002060768,0.0003350983,0.0001883837,0.0002907299,0.0001745517,0.0001622499,0.001722665],"category_scores_gemma":[0.0002811886,0.0001433652,0.0001491635,0.0001686344,0.0002330556,0.00009250075,0.0002458709,0.0003606175,0.0004414233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003051452,"about_ca_system_score_gemma":0.0002573137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002128896,"about_ca_topic_score_gemma":0.001677378,"domain_scores_codex":[0.9998727,0.00001877404,0.000006423405,0.00003492893,0.00002860517,0.00003852353],"domain_scores_gemma":[0.9998825,0.00002807909,0.00002999223,0.00001410757,0.00001611042,0.0000292022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002538782,0.00002032869,0.002486227,0.00003780128,0.000009162596,0.00009142054,0.00002958727,0.0001179449,0.9933702,0.0001599436,0.0001284989,0.003295097],"study_design_scores_gemma":[0.00003200946,0.0002163149,0.0858734,0.00001484586,0.00006781,0.0007274223,0.00007295829,0.002594403,0.9036925,0.0002684965,0.006424682,0.00001520253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906664,0.004474537,0.003020615,0.0001258035,0.00002665406,0.00001470487,0.0003926525,0.00008848033,0.001190115],"genre_scores_gemma":[0.9962246,0.0007359789,0.0008888614,0.00005007062,0.00001648036,0.00001011312,0.0007120781,0.00002221375,0.001339503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002128896,"threshold_uncertainty_score":0.005762875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395517848351733,"score_gpt":0.2389770433451797,"score_spread":0.2250218648616623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}