{"id":"W2787958089","doi":"10.1016/j.celrep.2018.01.070","title":"Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Turun Yliopistollinen Keskussairaala; Varsinais-Suomen Sairaanhoitopiiri; Biocenter Finland; Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg; Sigrid Juséliuksen Säätiö; Turun Yliopisto; Sweden-Japan Foundation; Gemeinnützige Hertie-Stiftung; Tekes; Biogen; California Department of Fish and Game; Else Kröner-Fresenius-Stiftung; Juvenile Diabetes Research Foundation Australia; European Commission; Åbo Akademi; Juvenile Diabetes Research Foundation United Kingdom; Juvenile Diabetes Research Foundation International; American Osteopathic Foundation; BC Children’s Hospital Foundation; Bundesministerium für Bildung und Forschung; Paulon Säätiö; Canadian Institute of Mining, Metallurgy and Petroleum; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Academy of Finland","keywords":"Effector; FOXP3; Biology; Immune system; Transcription factor; Repressor; In vitro; Cell biology; Downregulation and upregulation; Transcriptional regulation; Gene; Regulation of gene expression; Function (biology); Cancer research; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002838063,0.0001636852,0.0002735428,0.0001850417,0.0002221775,0.00001299416,0.00008531602,0.0002754658,0.003708529],"category_scores_gemma":[0.00005578268,0.0001584995,0.0001346359,0.000135201,0.0001516568,0.0001259001,0.0000382484,0.0002167596,0.0003286802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005496655,"about_ca_system_score_gemma":0.00005477623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006775323,"about_ca_topic_score_gemma":0.000007902332,"domain_scores_codex":[0.9985614,0.0001126386,0.0006254599,0.0003965631,0.00006282712,0.0002410912],"domain_scores_gemma":[0.9986507,0.00004234164,0.0003743968,0.0004844361,0.0004190649,0.00002904094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002870132,0.0001451838,0.0005078074,0.00001546881,0.00008333645,0.000006231729,0.0002381219,0.000002878008,0.9376079,0.0002736551,0.06055536,0.0002770149],"study_design_scores_gemma":[0.0004660994,0.0004789126,0.0181345,0.00003546759,0.00005918651,0.00003567567,0.0001294592,5.788195e-7,0.8428265,0.0001656071,0.1375418,0.0001262231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737972,0.0003790611,0.00041503,0.00007524123,0.01226692,0.0003276583,0.000003059539,0.00007484027,0.01266097],"genre_scores_gemma":[0.9623988,0.000003468975,0.00001232208,0.0002385266,0.00009395409,0.0000268938,0.0001276011,0.00001817855,0.03708027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09478142,"threshold_uncertainty_score":0.9972022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395517848351733,"score_gpt":0.2389770433451797,"score_spread":0.2250218648616623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}