{"id":"W2788004032","doi":"10.1016/j.molcel.2018.01.027","title":"Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2","year":2018,"lang":"en","type":"article","venue":"Molecular Cell","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Niilo Helanderin Säätiö; European Research Council; Medical Research Council; Medical Research Council Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Lister Institute of Preventive Medicine; National Institute for Health and Care Research; Breast Cancer Now","keywords":"Biology; Ubiquitin; IκB kinase; Cell biology; Kinase; RIPK1; Posttranslational modification; Ubiquitin ligase; Signal transduction; Genetics; Biochemistry; Enzyme; NF-κB; Apoptosis; Gene; Programmed cell death","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001935114,0.0001242395,0.0001545957,0.00005214176,0.00002746076,0.000005910653,0.0001093595,0.000161358,0.00002531858],"category_scores_gemma":[0.00006414848,0.0001308055,0.00006224232,0.00008602629,0.0001683267,0.000002996174,0.0001173004,0.00005946663,0.000004527247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007875213,"about_ca_system_score_gemma":0.00005366463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000348414,"about_ca_topic_score_gemma":0.0000126123,"domain_scores_codex":[0.999124,0.00008235277,0.0001865249,0.0002765941,0.0001763588,0.0001541956],"domain_scores_gemma":[0.999249,0.0000105699,0.0001762205,0.0003466962,0.000155177,0.00006230468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008955903,0.00008711511,0.0007026647,0.00005241925,0.00002219224,0.000004007243,0.00005496644,0.0000164255,0.9979669,0.00004508458,0.00007632156,0.0008823565],"study_design_scores_gemma":[0.0005632906,0.000424584,0.003352968,0.00001608122,0.00002323355,0.000002864719,0.00001386169,0.000141561,0.9943162,0.00008672843,0.0009359523,0.0001226443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923403,0.0002700075,0.00522976,0.00002076479,0.00005928601,0.0001463756,0.00002628608,0.000007637995,0.001899549],"genre_scores_gemma":[0.9988987,0.00001459022,0.0007908549,0.00004965931,0.00005029341,0.000004410827,0.00005607413,0.00002093841,0.0001144711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006558375,"threshold_uncertainty_score":0.5334092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006999834008634707,"score_gpt":0.2174268505006287,"score_spread":0.210427016491994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}