{"id":"W2788004032","doi":"10.1016/j.molcel.2018.01.027","title":"Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2","year":2018,"lang":"en","type":"article","venue":"Molecular Cell","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Niilo Helanderin Säätiö; European Research Council; Medical Research Council; Medical Research Council Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Lister Institute of Preventive Medicine; National Institute for Health and Care Research; Breast Cancer Now","keywords":"Biology; Ubiquitin; IκB kinase; Cell biology; Kinase; RIPK1; Posttranslational modification; Ubiquitin ligase; Signal transduction; Genetics; Biochemistry; Enzyme; NF-κB; Apoptosis; Gene; Programmed cell death","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678919,0.0004122426,0.0001471238,0.000170339,0.0001524088,0.0002832653,0.0002587521,0.000130354,0.001702096],"category_scores_gemma":[0.0001101824,0.0001229055,0.0002107239,0.0001279026,0.0002290808,0.00025053,0.0002510477,0.0003494116,0.0006448959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000414923,"about_ca_system_score_gemma":0.0002026172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001716588,"about_ca_topic_score_gemma":0.0003192532,"domain_scores_codex":[0.9998873,0.00001563951,0.00001262387,0.0000318441,0.00002381965,0.00002864397],"domain_scores_gemma":[0.9999076,0.000009195055,0.00003425702,0.0000210318,0.000009440611,0.00001847908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001119489,0.00002388602,0.0001786509,0.00004725632,0.000004528361,0.00003253199,0.000007717561,0.00005886778,0.9974328,0.0003265245,0.00006459013,0.001710699],"study_design_scores_gemma":[0.00001276445,0.00007540578,0.002913608,0.000003423566,0.000009101776,0.0001843877,0.000008967969,0.0005305548,0.9930923,0.00007573442,0.003089898,0.000003865519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815403,0.005495444,0.006614206,0.000155911,0.0000901095,0.00003798362,0.0006460847,0.0002559188,0.00516405],"genre_scores_gemma":[0.9936864,0.0009234215,0.002058479,0.00003909878,0.000009988218,0.00002625514,0.0004729672,0.00002640857,0.00275708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001702096,"threshold_uncertainty_score":0.005694091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006999834008634707,"score_gpt":0.2174268505006287,"score_spread":0.210427016491994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}