{"id":"W2788144601","doi":"10.1016/j.cub.2018.01.047","title":"Remodeling the Specificity of an Endosomal CORVET Tether Underlies Formation of Regulated Secretory Vesicles in the Ciliate Tetrahymena thermophila","year":2018,"lang":"en","type":"article","venue":"Current Biology","topic":"Protist diversity and phylogeny","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph; University of Alberta","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Tetrahymena; Biology; Endosome; Cell biology; Endocytic cycle; Biogenesis; Vacuolar protein sorting; Protein targeting; Ciliate; Vacuole; Organelle; Contractile vacuole; Protein subunit; Endocytosis; Genetics; Membrane protein; Cytoplasm; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001316366,0.0001214827,0.0002384401,0.0001762215,0.0005038727,0.0005374397,0.000361358,0.0006405177,0.0007139984],"category_scores_gemma":[0.0002820553,0.0002651572,0.0002496075,0.0001062815,0.0004489716,0.0005053325,0.0008055795,0.0005342878,0.0003757667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004551662,"about_ca_system_score_gemma":0.0002330398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001184194,"about_ca_topic_score_gemma":0.002443543,"domain_scores_codex":[0.9999001,0.000008186743,0.000007945464,0.00003107351,0.00002422623,0.00002841253],"domain_scores_gemma":[0.9998187,0.00002410693,0.00004920573,0.00003728041,0.00002689523,0.00004372593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000540318,0.000006090223,0.001805301,0.00001770855,0.000004225314,0.0001033993,0.0000615919,0.0001851686,0.9962443,0.0004412484,0.00003987123,0.001037081],"study_design_scores_gemma":[0.00003481569,0.000144888,0.3035848,0.00002176852,0.0000336843,0.0008432367,0.0007225198,0.02121405,0.6694499,0.00110165,0.002797645,0.00005095524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983141,0.00009611299,0.001076454,0.00006262613,0.000008371416,0.000003388874,0.00004568801,0.00003155834,0.0003616954],"genre_scores_gemma":[0.9991571,0.00003310792,0.0003431037,0.00002778583,0.000001649617,0.000002981267,0.00005616967,0.00001284874,0.0003652532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001184194,"threshold_uncertainty_score":0.003302515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04174481311742814,"score_gpt":0.2848496195816259,"score_spread":0.2431048064641977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}