{"id":"W2788161716","doi":"10.1016/j.bbrc.2018.02.016","title":"Crystal structure of chromo barrel domain of RBBP1","year":2018,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Biotech; Innovative Medicines Initiative; Ontario Ministry of Research, Innovation and Science; Wellcome Trust; Mount Sylvia Diatomite; National Natural Science Foundation of China; Ontario Genomics Institute; Canada Foundation for Innovation; Genome Canada; AbbVie; Merck KGaA; Boehringer Ingelheim; Pfizer","keywords":"Histone; Chemistry; HMG-box; Biophysics; Binding domain; DNA; DNA-binding domain; Biochemistry; Cell biology; Binding site; Biology; Molecular biology; DNA-binding protein; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691685,0.0002618803,0.0003265074,0.0001639183,0.0004476381,0.0003821767,0.0004086802,0.0003548874,0.00215639],"category_scores_gemma":[0.0002519788,0.0001455151,0.0001344734,0.0002701939,0.0001734661,0.0002545767,0.0001823106,0.0008054141,0.0004678542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000929858,"about_ca_system_score_gemma":0.0006567824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003196031,"about_ca_topic_score_gemma":0.002796188,"domain_scores_codex":[0.9999499,0.000005890997,0.000003089591,0.00001014562,0.00001658623,0.00001439254],"domain_scores_gemma":[0.9999044,0.00002190975,0.00002293441,0.00000297796,0.00001510421,0.00003273862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004358213,0.0003970028,0.009327095,0.001182875,0.0001213701,0.002306641,0.0007245725,0.005112881,0.9332194,0.00698887,0.01487202,0.02138895],"study_design_scores_gemma":[0.0008427973,0.0007683199,0.109611,0.0002986954,0.0003238683,0.004585158,0.002295888,0.07130294,0.6979121,0.00400878,0.1078076,0.000242918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815006,0.005313372,0.003157242,0.0009799217,0.0001840275,0.00003713246,0.003679332,0.0003940962,0.004754242],"genre_scores_gemma":[0.9871235,0.001608588,0.002675714,0.0001516835,0.00001880472,0.0000215503,0.005011152,0.0000257004,0.003363403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003196031,"threshold_uncertainty_score":0.007213771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04744104664919913,"score_gpt":0.3699335995179121,"score_spread":0.322492552868713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}