{"id":"W2788202668","doi":"10.1371/journal.pone.0193344","title":"A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Cancer Society Research Institute","keywords":"Protein kinase B; AKT1; AKT2; Cancer research; Carcinogenesis; Cell growth; PI3K/AKT/mTOR pathway; Biology; Cell cycle; Chemistry; Phosphorylation; Signal transduction; Cell biology; Cell; Cancer; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334793,0.0004362757,0.0004144587,0.0003312259,0.0001655779,0.0002765787,0.0002040984,0.0002473399,0.00128661],"category_scores_gemma":[0.00007745245,0.0001513603,0.000375041,0.0003250628,0.0001677802,0.0001763792,0.0001234565,0.0006313421,0.0003840189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002489907,"about_ca_system_score_gemma":0.0005360789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001481071,"about_ca_topic_score_gemma":0.004066956,"domain_scores_codex":[0.9999322,0.00001010968,0.00001100055,0.00001243422,0.00001780654,0.00001659635],"domain_scores_gemma":[0.9999545,0.000008495696,0.00001009789,0.000004011575,0.000005135778,0.00001775034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000763276,0.0004386061,0.0005552609,0.0001780292,0.00003450335,0.00008032443,0.00002839933,0.0003629138,0.9852347,0.0002921287,0.0003141618,0.01171779],"study_design_scores_gemma":[0.0002508523,0.004295015,0.008408322,0.00001255755,0.00007487385,0.0005980111,0.00003808899,0.00124939,0.9794419,0.00007138656,0.005547476,0.00001220769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889411,0.004890368,0.00158411,0.0001441644,0.00006847045,0.00007978598,0.0006233542,0.0001377797,0.003530838],"genre_scores_gemma":[0.9921792,0.003128553,0.001926182,0.00006178837,0.00001035705,0.00004210982,0.0008521336,0.00001415389,0.001785543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001481071,"threshold_uncertainty_score":0.004304111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02914080608207691,"score_gpt":0.2650613148156729,"score_spread":0.2359205087335959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}