{"id":"W2788362569","doi":"10.1371/journal.pgen.1007214","title":"CDK activity provides temporal and quantitative cues for organizing genome duplication","year":2018,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre National de la Recherche Scientifique; Conseil Régional de Bretagne; Fondation ARC pour la Recherche sur le Cancer; Institute of Genetics; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale","keywords":"Cyclin-dependent kinase; Biology; Replication timing; DNA replication; Cell biology; Cell cycle; Computational biology; Gene duplication; Genetics; Cyclin; DNA; Cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001000526,0.0001207275,0.0001047204,0.00002589114,0.0001066903,0.0000299214,0.0001055625,0.0001013013,0.000004661651],"category_scores_gemma":[0.0001132969,0.0001217608,0.00002979415,0.00005133347,0.00009906173,0.000004338853,0.0001003494,0.00003263021,0.000007640545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001196841,"about_ca_system_score_gemma":0.00004844907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002685286,"about_ca_topic_score_gemma":0.00003677045,"domain_scores_codex":[0.9992754,0.00002868629,0.0001107229,0.0003326026,0.00007761385,0.0001749652],"domain_scores_gemma":[0.9994028,0.00001554525,0.0000803521,0.0002516818,0.000191584,0.00005807922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005619919,0.00005043665,0.001234019,0.00003307924,0.00004305543,1.583429e-7,0.0001463349,0.000001265096,0.9974619,0.0001495605,0.00005761989,0.0007663642],"study_design_scores_gemma":[0.0002306103,0.0009690459,0.00119367,0.000006222494,0.00003105259,0.00000292836,0.00007351338,0.002009694,0.9912143,0.0005067529,0.003602564,0.0001596721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877144,0.0004479286,0.01107036,0.0001038942,0.00005089174,0.0004631765,0.00002865477,0.00002549205,0.00009526909],"genre_scores_gemma":[0.9684565,0.00006811581,0.03087402,0.00008584625,0.0002333089,0.00005229844,0.00004822412,0.000033468,0.0001482082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01980366,"threshold_uncertainty_score":0.496526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03150757436989585,"score_gpt":0.2832066134679971,"score_spread":0.2516990390981013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}