{"id":"W2788362569","doi":"10.1371/journal.pgen.1007214","title":"CDK activity provides temporal and quantitative cues for organizing genome duplication","year":2018,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre National de la Recherche Scientifique; Conseil Régional de Bretagne; Fondation ARC pour la Recherche sur le Cancer; Institute of Genetics; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale","keywords":"Cyclin-dependent kinase; Biology; Replication timing; DNA replication; Cell biology; Cell cycle; Computational biology; Gene duplication; Genetics; Cyclin; DNA; Cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002728564,0.0003381844,0.0003637698,0.0006465058,0.0003579637,0.001596436,0.0004416403,0.0004563661,0.001496149],"category_scores_gemma":[0.0007792064,0.000400333,0.0002131624,0.0004718146,0.000607832,0.001126766,0.000808089,0.0005720387,0.0009617314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008527787,"about_ca_system_score_gemma":0.0005760188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008948241,"about_ca_topic_score_gemma":0.001717306,"domain_scores_codex":[0.9996953,0.00002677486,0.00002443943,0.0001191311,0.0000827055,0.00005165558],"domain_scores_gemma":[0.999684,0.00007496031,0.00007817507,0.00005058176,0.0000504132,0.00006190743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001652783,0.00001890249,0.001398801,0.0001526848,0.000008000437,0.0001276782,0.00005616841,0.001887942,0.9692066,0.007340285,0.0003352274,0.01930242],"study_design_scores_gemma":[0.00005036662,0.0001388465,0.01659318,0.00005071936,0.00003984412,0.0006309951,0.0001645012,0.01344245,0.9238274,0.008564735,0.03643086,0.00006607203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7980581,0.03595893,0.1395933,0.001089721,0.0004079353,0.0001017273,0.002578381,0.001850422,0.02036143],"genre_scores_gemma":[0.9780329,0.005172723,0.01404281,0.00008185676,0.00008531456,0.00002656555,0.0005057274,0.0001441448,0.001907912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001596436,"threshold_uncertainty_score":0.006187379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03150757436989585,"score_gpt":0.2832066134679971,"score_spread":0.2516990390981013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}