{"id":"W2788442932","doi":"10.1038/s41467-018-03321-w","title":"Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Health and Medical Research Council; Australian Research Council; Australian Synchrotron; Medical Research Council; Ludwig Institute for Cancer Research","keywords":"T-cell receptor; Epitope; Human leukocyte antigen; Polyclonal antibodies; T cell; Peptide sequence; Amino acid; Biology; Peptide; Receptor; Antigen; Cell biology; Chemistry; Immune system; Immunology; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108121,0.0001523215,0.0001598721,0.0001119504,0.0001010031,0.0005035794,0.000266873,0.0002615679,0.001154544],"category_scores_gemma":[0.0001812649,0.0001161041,0.0002222612,0.00008692118,0.0002122663,0.0002249403,0.0003473398,0.0004793216,0.0004878313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002166242,"about_ca_system_score_gemma":0.0001028239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002273926,"about_ca_topic_score_gemma":0.0001950244,"domain_scores_codex":[0.9998802,0.00001906536,0.000008428812,0.00002679734,0.00002392482,0.00004150441],"domain_scores_gemma":[0.9998749,0.00002289243,0.00003107533,0.00001602788,0.00001555649,0.00003944131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001093619,0.00001168824,0.0008356718,0.000009998511,0.000003999101,0.00006747003,0.00003223077,0.0001266702,0.9981046,0.0001385851,0.00001007685,0.000549667],"study_design_scores_gemma":[0.00008344559,0.001231367,0.07590223,0.00002642709,0.00006734597,0.004057938,0.0005189882,0.00750841,0.9067822,0.0009667951,0.002824755,0.00003002265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989052,0.000101902,0.0004336315,0.00000764883,0.000002315071,0.000001793675,0.00001582292,0.000005171752,0.0005266719],"genre_scores_gemma":[0.9993274,0.00003662511,0.0002912673,0.00001391543,0.000001710617,0.000001842943,0.00006010129,0.000003099619,0.0002641115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001154544,"threshold_uncertainty_score":0.003862321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02408371619767156,"score_gpt":0.2705648741467461,"score_spread":0.2464811579490745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}