{"id":"W2788462611","doi":"10.1158/1541-7786.mcr-17-0307","title":"A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 Activation","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Research Resources; U.S. National Library of Medicine; National Cancer Institute; National Institutes of Health; American Association for Cancer Research","keywords":"XBP1; Biology; Gene; Signal transduction; RNA interference; Unfolded protein response; Luciferase; Cell biology; Genetics; RNA splicing; Transfection; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000491338,0.0002270204,0.0001952064,0.0001714886,0.0004084596,0.00008963044,0.0004833873,0.0001884198,0.0002738612],"category_scores_gemma":[0.0002001642,0.0002176289,0.0001406496,0.0002905651,0.0004533108,0.00001368014,0.0004422872,0.0002445004,0.00005789227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001026136,"about_ca_system_score_gemma":0.0001855397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007536752,"about_ca_topic_score_gemma":0.000130392,"domain_scores_codex":[0.9973117,0.0002789424,0.0002186716,0.0006993642,0.0007886259,0.0007027388],"domain_scores_gemma":[0.9983936,0.00001714247,0.00008691944,0.0007465574,0.000410852,0.0003449482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001310665,0.00006468205,0.01706064,0.00003648304,0.0001058235,0.0000369403,0.00008022135,0.00006927971,0.9768027,0.0001346518,0.004735429,0.0007420669],"study_design_scores_gemma":[0.001175464,0.0003993097,0.06507199,0.00007702789,0.00003137536,0.000002708408,0.0001643596,0.00005992177,0.9173726,0.0004965967,0.01472985,0.0004188184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946315,0.0007715807,0.0005282884,0.0004061866,0.00008892554,0.0004691341,0.0000716447,0.00002379233,0.003008984],"genre_scores_gemma":[0.9970605,0.0002466967,0.0001096106,0.0004973495,0.0004654416,0.0001634004,0.0001932511,0.00005663629,0.001207059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05943014,"threshold_uncertainty_score":0.8874649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.048305653408697,"score_gpt":0.3675284835093634,"score_spread":0.3192228301006664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}