{"id":"W2788488195","doi":"10.1128/mcb.00023-18","title":"AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms","year":2018,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Kingston General Hospital; Queen's University","funders":"Cancer Research UK; National Institutes of Health; Biotechnology and Biological Sciences Research Council; National Institute of Neurological Disorders and Stroke; Tertiary Education Trust Fund; Research Councils UK","keywords":"Autophagy; mTORC1; ULK1; AMPK; Cell biology; Biology; Autophagosome; Lysosome; AMP-activated protein kinase; Phosphorylation; BAG3; Protein kinase A; Biochemistry; Sequestosome 1; Protein kinase B","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262773,0.0001511219,0.0001985369,0.00007718262,0.0001168971,0.00001611624,0.00004708712,0.0001592605,0.0000697732],"category_scores_gemma":[0.00001605127,0.0001275423,0.00004808114,0.00007174919,0.0001573924,0.00005445386,0.00004823135,0.00008524038,0.00003674258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000181366,"about_ca_system_score_gemma":0.00001977358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001146045,"about_ca_topic_score_gemma":0.000002261139,"domain_scores_codex":[0.9991385,0.00007258206,0.0001986486,0.0002901189,0.00009284318,0.00020732],"domain_scores_gemma":[0.9995102,0.00001019347,0.00007256075,0.0002128654,0.00006133001,0.0001328797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009458245,0.00005506039,0.0002259978,0.00003014875,0.00004437783,0.00003612375,0.0001393524,6.242258e-8,0.9811834,0.007159368,0.000005806844,0.01102574],"study_design_scores_gemma":[0.001094896,0.0005911338,0.002409927,0.00001505559,0.00008501352,0.0001397534,0.00003337688,0.0005521082,0.9806828,0.01375241,0.000504124,0.0001393429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8216458,0.001339332,0.1760784,0.0002099371,0.00008807162,0.0002403138,0.000007316534,0.00004861904,0.0003422267],"genre_scores_gemma":[0.9985161,0.00005580656,0.0004779638,0.0005365412,0.00009522297,0.0000213018,0.0001901638,0.00001630298,0.00009060808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1768703,"threshold_uncertainty_score":0.5201025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008073774212452723,"score_gpt":0.2441325353231698,"score_spread":0.236058761110717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}