{"id":"W2788488195","doi":"10.1128/mcb.00023-18","title":"AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms","year":2018,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Kingston General Hospital; Queen's University","funders":"Cancer Research UK; National Institutes of Health; Biotechnology and Biological Sciences Research Council; National Institute of Neurological Disorders and Stroke; Tertiary Education Trust Fund; Research Councils UK","keywords":"Autophagy; mTORC1; ULK1; AMPK; Cell biology; Biology; Autophagosome; Lysosome; AMP-activated protein kinase; Phosphorylation; BAG3; Protein kinase A; Biochemistry; Sequestosome 1; Protein kinase B","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002280951,0.0004117562,0.0004106281,0.0003019653,0.0001875348,0.0003569441,0.0001645633,0.0002247935,0.00104029],"category_scores_gemma":[0.0001341514,0.0001865674,0.0003569785,0.0001722356,0.0002123485,0.0002392325,0.000275553,0.0004720015,0.0002562106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002886565,"about_ca_system_score_gemma":0.0002945047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001627228,"about_ca_topic_score_gemma":0.0004104839,"domain_scores_codex":[0.9997677,0.00005682288,0.00003826852,0.00002844331,0.00004122503,0.00006750111],"domain_scores_gemma":[0.9999239,0.00001470612,0.00002189052,0.00001164014,0.000008822676,0.00001900708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00109495,0.00015659,0.0002307165,0.0001302889,0.00002137446,0.00005533674,0.00002035141,0.0001256791,0.9941181,0.0003479965,0.00009687582,0.003601823],"study_design_scores_gemma":[0.00006612312,0.0004622762,0.003594889,0.00001004118,0.00002027488,0.000149233,0.00001389957,0.0007663054,0.9926136,0.00009158434,0.002207117,0.000004815285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878536,0.005961765,0.00248032,0.0001740273,0.00008678738,0.00008080961,0.0002530943,0.00008355403,0.003026079],"genre_scores_gemma":[0.9926637,0.002472444,0.002086661,0.0001015822,0.0000335267,0.0001101945,0.0003620302,0.00001539688,0.002154563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104029,"threshold_uncertainty_score":0.003480077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008073774212452723,"score_gpt":0.2441325353231698,"score_spread":0.236058761110717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}