{"id":"W2788495409","doi":"10.1016/j.cell.2018.02.019","title":"Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; EMBO; National Institute on Aging; National Institutes of Health; Institut National de la Santé et de la Recherche Médicale; Japan Society for the Promotion of Science; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; Rockefeller University; National Institute of Allergy and Infectious Diseases; Université Paris Descartes; St. Giles Foundation; William and Ella Owens Medical Research Foundation; U.S. Department of Veterans Affairs","keywords":"Biology; Brainstem; Viral infection; Virology; RNA; Metabolism; Virus; Biochemistry; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005427449,0.00006045809,0.00006872586,0.00003780906,0.00002049113,0.000005170314,0.00004253288,0.00005859327,0.00003392248],"category_scores_gemma":[0.00000871884,0.00005163076,0.00003003315,0.00006610667,0.00006117599,0.000003241194,0.00002132613,0.00002562619,0.000008091319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004340106,"about_ca_system_score_gemma":0.00003459253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004929478,"about_ca_topic_score_gemma":0.0001850326,"domain_scores_codex":[0.9996131,0.00002824914,0.0000953514,0.0001263004,0.00005493944,0.00008206628],"domain_scores_gemma":[0.9997212,0.000001537469,0.00004821629,0.0001478788,0.00004385208,0.00003735718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001551795,0.0001104325,0.03126851,0.00002388808,0.00001230305,0.000001324948,0.0001359996,0.00007538599,0.9669384,0.0001956164,0.0006156291,0.0004673435],"study_design_scores_gemma":[0.001366978,0.0002093097,0.3010458,0.000009072263,0.00001765789,7.123991e-7,0.00003802052,0.00008455219,0.6765026,0.00006050349,0.02053636,0.000128416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893278,0.0001001187,0.0003688641,0.00002443888,0.00007562112,0.00007320993,0.000003580443,0.0000051598,0.01002124],"genre_scores_gemma":[0.9987422,0.00001036156,0.0001198827,0.0001125825,0.0001112004,0.000003701451,0.00002778436,0.000007812838,0.000864431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2904358,"threshold_uncertainty_score":0.2105441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006498954796567499,"score_gpt":0.2292475276371489,"score_spread":0.2227485728405814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}