{"id":"W2788589375","doi":"10.1093/jncics/pky023","title":"Oral Contraceptive Use and Breast Cancer Risk: Retrospective and Prospective Analyses From a BRCA1 and BRCA2 Mutation Carrier Cohort Study","year":2018,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; McMaster University; Juravinski Hospital","funders":"National Cancer Institute; Narodowe Centrum Badań i Rozwoju; National Institutes of Health; Institut Claudius Regaud; Freistaat Sachsen; Ministero dello Sviluppo Economico; National Health and Medical Research Council; Institut National Du Cancer; Deutsche Krebshilfe; Medizinische Universität Wien; Medical Research Council; Leids Universitair Medisch Centrum; Radboud Universitair Medisch Centrum; Fondation de France; Odense Universitetshospital; Rijksuniversiteit Groningen; Ministerio de Economía y Competitividad; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Australia; Universität Wien; Lunds Universitet; Universiteit Maastricht; Institut Gustave-Roussy; Vrije Universiteit Amsterdam; Instituto de Salud Carlos III; Radboud Universiteit; Cancer Research UK; Government of Canada; Hungarian Scientific Research Fund; Fondation du cancer du sein du Québec; European Regional Development Fund; Ministerstvo Školství, Mládeže a Tělovýchovy; National Breast Cancer Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; National Institute for Health and Care Research; Genome Canada; Maastricht Universitair Medisch Centrum; European Commission; Canadian Institutes of Health Research; Fundación Mutua Madrileña; Royal Marsden NHS Foundation Trust; Universiteit Leiden; Deutsches Krebsforschungszentrum","keywords":"Medicine; Retrospective cohort study; Prospective cohort study; Hazard ratio; Breast cancer; Proportional hazards model; Cohort study; Internal medicine; Relative risk; Confidence interval; Gynecology; Obstetrics; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001819167,0.0003249896,0.0003852465,0.0000827029,0.0003191339,0.0001685748,0.00009705983,0.0001550852,0.0001243366],"category_scores_gemma":[0.00008390527,0.0003055189,0.00004553152,0.0002239753,0.0005596609,0.00004851239,0.000147699,0.0002003661,0.000001447299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004119956,"about_ca_system_score_gemma":0.0002487072,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02537506,"about_ca_topic_score_gemma":0.04144068,"domain_scores_codex":[0.9979651,0.0001352699,0.0002603017,0.00107048,0.000240538,0.0003283249],"domain_scores_gemma":[0.9988891,0.00003164114,0.0002343876,0.0003485879,0.0003476343,0.0001486286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004477037,0.00006256729,0.9861802,0.000004715452,0.001084708,0.000006786141,0.002134059,0.00001928233,0.007951253,0.00001799712,0.0005219439,0.001568727],"study_design_scores_gemma":[0.001885831,0.0005747933,0.9728556,0.00002024406,0.0004898875,0.00002427322,0.001191122,0.0002439438,0.02170445,0.0004142185,0.0002209596,0.0003747325],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993064,0.002864994,0.0004359734,0.0002874896,0.0003171362,0.001051617,0.0018462,0.00002727328,0.0001053189],"genre_scores_gemma":[0.9965227,0.001493628,0.0002765905,0.0001549749,0.0008679405,0.0003805592,0.00003456188,0.00004798134,0.0002211142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01606562,"threshold_uncertainty_score":0.9999397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536754761930594,"score_gpt":0.3181364013296558,"score_spread":0.3027688537103499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}