{"id":"W2788635059","doi":"10.1186/s13148-017-0436-1","title":"The signature of liver cancer in immune cells DNA methylation","year":2018,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"Canadian Institutes of Health Research; Beijing Municipal Science and Technology Commission; National Natural Science Foundation of China","keywords":"Hepatocellular carcinoma; Immune system; DNA methylation; Peripheral blood mononuclear cell; Immunology; Liver cancer; Immunotherapy; Cancer; Biology; Methylation; Medicine; Cancer research; Gene; Internal medicine; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547243,0.00009862579,0.0001766306,0.0003241489,0.0001254232,0.0002116695,0.00008805461,0.000149583,0.001152191],"category_scores_gemma":[0.0003707653,0.00008849234,0.0001000626,0.0002494203,0.000167446,0.00008156683,0.0001872324,0.000197853,0.0002162216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000124461,"about_ca_system_score_gemma":0.0001165912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007298524,"about_ca_topic_score_gemma":0.001146518,"domain_scores_codex":[0.9998713,0.00002463904,0.000006519076,0.00005029092,0.00002755946,0.00001966213],"domain_scores_gemma":[0.9998649,0.00003142025,0.00004446115,0.00001635647,0.00002374115,0.00001914904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006907844,0.00002212963,0.136208,0.00009085747,0.00007648397,0.0001638624,0.0002230865,0.0001940431,0.8389539,0.000207313,0.0002275418,0.02294204],"study_design_scores_gemma":[0.00001520617,0.0003081309,0.8419447,0.00001197123,0.00007004344,0.001597322,0.0001511688,0.001127142,0.1514874,0.0006350832,0.002641466,0.00001046935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939892,0.001223636,0.002477607,0.00009112226,0.00000988947,0.0000123062,0.00070765,0.00004833821,0.001440414],"genre_scores_gemma":[0.9981163,0.0002275432,0.0007783328,0.00004685773,0.000006080939,0.000009296843,0.0002576384,0.000005304229,0.0005527146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152191,"threshold_uncertainty_score":0.003854454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02696051806644748,"score_gpt":0.3544362898326305,"score_spread":0.327475771766183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}