{"id":"W2788635059","doi":"10.1186/s13148-017-0436-1","title":"The signature of liver cancer in immune cells DNA methylation","year":2018,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"Canadian Institutes of Health Research; Beijing Municipal Science and Technology Commission; National Natural Science Foundation of China","keywords":"Hepatocellular carcinoma; Immune system; DNA methylation; Peripheral blood mononuclear cell; Immunology; Liver cancer; Immunotherapy; Cancer; Biology; Methylation; Medicine; Cancer research; Gene; Internal medicine; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001056655,0.0001272594,0.0001968608,0.00002908168,0.00008257426,0.0000141029,0.0002664878,0.000333,0.00003111329],"category_scores_gemma":[0.0003972753,0.00009799046,0.0001350717,0.0001528023,0.0003822788,0.000002004777,0.0001191277,0.000167674,0.000009592175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009780375,"about_ca_system_score_gemma":0.000102945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004372355,"about_ca_topic_score_gemma":0.0004131154,"domain_scores_codex":[0.9983699,0.0002417572,0.0007184189,0.0002958428,0.0001536011,0.0002204236],"domain_scores_gemma":[0.9987562,0.0002030507,0.000257881,0.0004600589,0.0002592886,0.00006346897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001046782,0.00009425732,0.009179968,0.00001050106,0.0000418329,6.470229e-7,0.00005729411,0.0003986473,0.898676,0.0001040856,0.0001904614,0.09114162],"study_design_scores_gemma":[0.0003661417,0.0004834583,0.104914,0.00001581012,0.00002127516,8.704795e-8,0.00001523129,0.0007760592,0.8558125,0.0006768281,0.03678718,0.000131412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775237,0.01812644,0.002596769,0.0001734671,0.0007835985,0.0002266534,0.00001888355,0.000004655924,0.000545797],"genre_scores_gemma":[0.9782131,0.0199241,0.0007830167,0.00009011746,0.0005949675,0.00001031399,0.00001305404,0.00002028866,0.0003509756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09573403,"threshold_uncertainty_score":0.3995935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02696051806644748,"score_gpt":0.3544362898326305,"score_spread":0.327475771766183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}