{"id":"W2788772427","doi":"10.1074/jbc.ra118.001921","title":"An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Science Foundation Ireland; Wellcome Trust","keywords":"Proinflammatory cytokine; Fatty acid synthase; TLR4; Chemistry; Biochemistry; Signal transduction; Macrophage; Inflammation; Cell biology; Biology; Fatty acid; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003588524,0.0002096452,0.0003081983,0.00004873145,0.00006282677,0.00003535668,0.0002625416,0.0005211596,0.00005391556],"category_scores_gemma":[0.0005894037,0.0001594966,0.00007575937,0.0001161465,0.0002484404,0.00002190636,0.00007737823,0.0003469331,0.000002082954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004775232,"about_ca_system_score_gemma":0.00007311213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001599466,"about_ca_topic_score_gemma":5.620242e-7,"domain_scores_codex":[0.998702,0.0001283782,0.0004687055,0.0003127419,0.0001377892,0.0002503501],"domain_scores_gemma":[0.9990362,0.00003933988,0.0003367075,0.0002182007,0.0001588786,0.0002106777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002639563,0.00006441055,0.05653239,0.00002172659,0.00004448578,0.000008080063,0.00002634709,0.000001102256,0.9365677,2.130449e-7,0.00001662644,0.00645295],"study_design_scores_gemma":[0.0004984945,0.0004119475,0.03589116,0.00006096113,0.0000116833,0.00005424692,0.00006935042,0.000007747956,0.962396,0.00001740371,0.000399133,0.000181926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992095,0.0001527356,0.0002534364,0.0001479901,0.00003776254,0.00008893792,0.00001357881,0.00001198634,0.00008402696],"genre_scores_gemma":[0.9977176,0.00009153227,0.0006333597,0.00005331005,0.001448467,0.000009592931,0.00002256417,0.00001692014,0.000006700628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02582823,"threshold_uncertainty_score":0.6504081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599415755397101,"score_gpt":0.264334489985583,"score_spread":0.2483403324316119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}