{"id":"W2788772427","doi":"10.1074/jbc.ra118.001921","title":"An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Science Foundation Ireland; Wellcome Trust","keywords":"Proinflammatory cytokine; Fatty acid synthase; TLR4; Chemistry; Biochemistry; Signal transduction; Macrophage; Inflammation; Cell biology; Biology; Fatty acid; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001960545,0.0003180623,0.0001795507,0.0001986509,0.0001581282,0.000230358,0.0001222246,0.0002317744,0.0005580838],"category_scores_gemma":[0.0001418446,0.00009769295,0.0001208871,0.0001971608,0.0003271742,0.0002846704,0.000210754,0.0003782457,0.0001878021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002777533,"about_ca_system_score_gemma":0.000372335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002338153,"about_ca_topic_score_gemma":0.0003328587,"domain_scores_codex":[0.9999297,0.00001235605,0.000005331988,0.00001606475,0.00002001234,0.00001647912],"domain_scores_gemma":[0.9999183,0.00001974616,0.00001922714,0.000007860083,0.00001092804,0.00002393849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001955858,0.00001810143,0.0004811184,0.00007755399,0.000005013356,0.0002858034,0.00001170643,0.0001021005,0.9955995,0.0008151796,0.00002790767,0.002380366],"study_design_scores_gemma":[0.00003120505,0.0001666862,0.008070065,0.00001147501,0.00002786363,0.0009028894,0.00002615141,0.001224034,0.9836075,0.001300898,0.004622166,0.000009015527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581278,0.01715426,0.01976305,0.001027047,0.0001560341,0.00003771267,0.0002610374,0.000117814,0.003355233],"genre_scores_gemma":[0.9871827,0.004968599,0.005960483,0.0001225742,0.00005178021,0.00002471977,0.0001780061,0.00001008551,0.001501035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005580838,"threshold_uncertainty_score":0.002015293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599415755397101,"score_gpt":0.264334489985583,"score_spread":0.2483403324316119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}