{"id":"W2788789448","doi":"10.1089/crispr.2017.0009","title":"Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa","year":2018,"lang":"en","type":"article","venue":"The CRISPR Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Eye Institute; Charles A. King Trust; Research to Prevent Blindness","keywords":"Retinitis pigmentosa; Allele; Biology; Genetics; CRISPR; Cas9; Mutant; Genome editing; Rhodopsin; Gene; Retinal","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840559,0.0003729769,0.0003866844,0.0002306536,0.0002378059,0.0002954691,0.0003494191,0.0004623455,0.001372392],"category_scores_gemma":[0.000211656,0.0001480396,0.000401521,0.0001262588,0.000204949,0.0001707326,0.0003348282,0.0006208213,0.0004283462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000280918,"about_ca_system_score_gemma":0.00037843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005796164,"about_ca_topic_score_gemma":0.001347478,"domain_scores_codex":[0.9997559,0.00003423308,0.00002358882,0.00005982957,0.00009910716,0.00002730642],"domain_scores_gemma":[0.9998969,0.0000209461,0.00003343528,0.00002066554,0.000009749719,0.00001824813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002182488,0.00001418748,0.00009198358,0.00004327831,0.000009116663,0.0001212858,0.00001116007,0.0001484358,0.9956771,0.0002661413,0.00007656372,0.003518904],"study_design_scores_gemma":[0.000008118282,0.0001270047,0.0009586199,0.000005464284,0.00002104261,0.0009356525,0.00001183657,0.001382387,0.9914818,0.00009153314,0.00496624,0.00001039936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8588994,0.003670507,0.1275573,0.0003398934,0.0002189957,0.0003051248,0.001113773,0.001630196,0.006264801],"genre_scores_gemma":[0.9643509,0.001204361,0.02998072,0.00007186869,0.00001232556,0.00007731002,0.0005274597,0.0001223865,0.003652584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372392,"threshold_uncertainty_score":0.004591107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02086845549116657,"score_gpt":0.2924181890584948,"score_spread":0.2715497335673283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}