{"id":"W2788793247","doi":"10.1016/j.str.2018.01.015","title":"Conservation of Dynamics Associated with Biological Function in an Enzyme Superfamily","year":2018,"lang":"en","type":"article","venue":"Structure","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université Laval; PROTEO; Université du Québec à Montréal; Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Armand-Frappier Foundation","keywords":"SUPERFAMILY; Function (biology); Enzyme; Computational biology; Biology; Chemistry; Evolutionary biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006440265,0.0001146373,0.0001245647,0.00003583483,0.0000352062,0.0000078597,0.0001024296,0.000280235,0.00001872924],"category_scores_gemma":[0.00005842803,0.00008599933,0.00002127122,0.00014103,0.0001690808,0.000006074645,0.00002838009,0.00009107256,2.779896e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002035656,"about_ca_system_score_gemma":0.00005045672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003481745,"about_ca_topic_score_gemma":0.003455712,"domain_scores_codex":[0.9993494,0.00005594076,0.000142631,0.0002276644,0.00008147317,0.0001428831],"domain_scores_gemma":[0.9995356,0.000006083966,0.00007785933,0.0001995791,0.0001495757,0.00003135529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000517653,0.00002670791,0.296846,0.000006909185,0.00003752502,0.000001544997,0.0000574773,0.0000707272,0.6993623,0.001362028,0.00006179736,0.001649321],"study_design_scores_gemma":[0.001145651,0.003063659,0.9073451,0.00002273897,0.00002138467,0.00001133343,0.000145548,0.002880948,0.0802657,0.004535259,0.000272654,0.0002900281],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973891,0.00004547735,0.002048862,0.0000285476,0.00009045503,0.0001267172,0.00008958216,0.0000104619,0.0001707375],"genre_scores_gemma":[0.9980307,0.000004550769,0.0005859244,0.0002358491,0.0001073098,0.000002844162,0.0009997368,0.00001067006,0.00002244942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6190966,"threshold_uncertainty_score":0.3506951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008080454810519942,"score_gpt":0.2250685967640069,"score_spread":0.216988141953487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}