{"id":"W2788886885","doi":"10.3233/jhd-170282","title":"HttQ111/+ Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction","year":2018,"lang":"en","type":"article","venue":"Journal of Huntington s Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; CHDI Foundation","keywords":"Neuroscience; Huntington's disease; Postsynaptic potential; AMPA receptor; Neurodegeneration; Glutamatergic; Excitatory postsynaptic potential; Biology; NMDA receptor; Postsynaptic density; Synapse; Striatum; Neurotransmission; Electrophysiology; Inhibitory postsynaptic potential; Pathology; Medicine; Glutamate receptor; Disease; Receptor; Dopamine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003156252,0.001286511,0.0005833105,0.0009203903,0.0004340774,0.0006295278,0.0004271297,0.001164473,0.00551706],"category_scores_gemma":[0.0001831717,0.0005501374,0.0004738595,0.0004023788,0.00081299,0.00039335,0.0004049338,0.001559536,0.001318873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003717021,"about_ca_system_score_gemma":0.0002445301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001098527,"about_ca_topic_score_gemma":0.003260608,"domain_scores_codex":[0.9996114,0.00003329269,0.00007555557,0.0001222276,0.0001045146,0.00005300083],"domain_scores_gemma":[0.9993958,0.00008133867,0.0002796077,0.000041394,0.00003847557,0.0001632936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002297388,0.0001029662,0.0004281167,0.00006961992,0.00002807579,0.0001686941,0.00003846593,0.00006185679,0.9980339,0.00008814011,0.0001145737,0.0006357422],"study_design_scores_gemma":[0.0002957165,0.0009252742,0.0392924,0.00005973544,0.0001508953,0.002812635,0.0001436343,0.001534338,0.9507285,0.0002570482,0.003769391,0.00003047713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858056,0.000514837,0.005482166,0.0003172704,0.00006145395,0.0001135912,0.005668341,0.0004515277,0.001585231],"genre_scores_gemma":[0.9531115,0.001552573,0.01904037,0.0004852681,0.00005520211,0.0006032823,0.007964003,0.0007054323,0.01648241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00551706,"threshold_uncertainty_score":0.0184564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03639601423198897,"score_gpt":0.2661565402067707,"score_spread":0.2297605259747817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}