{"id":"W2788900890","doi":"10.1007/164_2018_99","title":"pH Modulation of Voltage-Gated Sodium Channels","year":2018,"lang":"en","type":"review","venue":"Handbook of experimental pharmacology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Sodium channel; Gating; Biophysics; Skeletal muscle; Chemistry; Sodium; Ion channel; Cardiac muscle; Electrophysiology; Membrane potential; Neuroscience; Internal medicine; Medicine; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001389866,0.0003203792,0.0007834013,0.0001688188,0.00005168498,0.000005262918,0.0001998356,0.0004613947,0.0004669244],"category_scores_gemma":[0.00001489451,0.0002998316,0.0003744883,0.0001170567,0.0002500093,0.000006088967,0.0001429448,0.00009557835,0.00002706248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003998979,"about_ca_system_score_gemma":0.0001212443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005566168,"about_ca_topic_score_gemma":2.245573e-7,"domain_scores_codex":[0.9984328,0.0001370431,0.0006516165,0.0004177811,0.0001444311,0.0002163849],"domain_scores_gemma":[0.9989338,0.00002087364,0.0006004378,0.0002199708,0.0001501428,0.00007480387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002624302,0.0003500606,0.00000118713,0.001578365,0.0004527323,0.000001661496,0.0001005167,0.00002989495,0.9485136,0.00002098626,0.01864612,0.0300424],"study_design_scores_gemma":[0.0005323249,0.0003970074,2.150207e-7,0.0003772999,0.0001099683,0.00001012618,0.00001431956,0.0001487229,0.5187879,0.000003437216,0.4794617,0.0001569117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008183902,0.9934293,0.001214918,0.000003043111,0.003333791,0.000704538,0.00005349422,0.00001447266,0.000428058],"genre_scores_gemma":[0.01284664,0.9824768,0.0001289371,0.00005548092,0.001917127,0.00009470714,0.001236602,0.00006104527,0.001182677],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4608156,"threshold_uncertainty_score":0.9999454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04206201712792802,"score_gpt":0.354886774062636,"score_spread":0.312824756934708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}