{"id":"W2788924848","doi":"10.15252/embr.201744981","title":"PINK1 autophosphorylation is required for ubiquitin recognition","year":2018,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Division of Materials Research; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; National Science Foundation; Canadian Institutes of Health Research; Parkinson Canada; Canada Research Chairs; National Institutes of Health; Government of Canada; Parkinson Society Canada; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Johns Hopkins University; Michael J. Fox Foundation for Parkinson's Research","keywords":"Autophosphorylation; Ubiquitin; Cell biology; Chemistry; Food science; Biology; Computational biology; Business; Biochemistry; Phosphorylation; Gene; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003640029,0.0001240845,0.0001106976,0.00002963689,0.0001364325,0.00002729115,0.00005648319,0.0001707654,0.0002367029],"category_scores_gemma":[0.0001935088,0.0001283193,0.000097483,0.00006077399,0.00006274752,0.000005854045,0.00004155663,0.00003982717,0.0000458273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001362231,"about_ca_system_score_gemma":0.00007689802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001089012,"about_ca_topic_score_gemma":0.000009125627,"domain_scores_codex":[0.9989491,0.00002462212,0.0002923877,0.0004024483,0.0001096244,0.0002217877],"domain_scores_gemma":[0.9991455,0.00000767357,0.000195058,0.0003467403,0.0002362603,0.00006875404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001833037,0.00005673224,0.0006551006,0.0000418309,0.00004499208,0.00001726425,0.0002062722,5.207486e-7,0.9124363,0.00005298028,0.04379631,0.04250837],"study_design_scores_gemma":[0.0001788453,0.0004418578,0.0004189376,0.0000179876,0.00001278357,0.00008825057,0.00001648567,0.00003229293,0.7978063,0.003140171,0.1976874,0.000158662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779418,0.0002315144,0.004800257,0.0002623271,0.0006871993,0.0005986707,0.00004428947,0.00005283103,0.01538114],"genre_scores_gemma":[0.9908215,0.00002266177,0.00348267,0.000847906,0.001213976,0.0001382742,0.000556813,0.0000303479,0.002885816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1538911,"threshold_uncertainty_score":0.523271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847593035820968,"score_gpt":0.2780312002011107,"score_spread":0.249555269842901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}