{"id":"W2788924848","doi":"10.15252/embr.201744981","title":"PINK1 autophosphorylation is required for ubiquitin recognition","year":2018,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Division of Materials Research; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; National Science Foundation; Canadian Institutes of Health Research; Parkinson Canada; Canada Research Chairs; National Institutes of Health; Government of Canada; Parkinson Society Canada; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Johns Hopkins University; Michael J. Fox Foundation for Parkinson's Research","keywords":"Autophosphorylation; Ubiquitin; Cell biology; Chemistry; Food science; Biology; Computational biology; Business; Biochemistry; Phosphorylation; Gene; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003118874,0.0006627277,0.0004698873,0.0004129453,0.0006532494,0.001287467,0.0005588405,0.0004925559,0.003798513],"category_scores_gemma":[0.0004908597,0.0004961745,0.000439471,0.0002744563,0.0004482378,0.001064526,0.0008815394,0.00103434,0.003000126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001429199,"about_ca_system_score_gemma":0.0005534893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001353716,"about_ca_topic_score_gemma":0.002602583,"domain_scores_codex":[0.9996641,0.00002943803,0.00003651417,0.0001109118,0.00007687506,0.00008230087],"domain_scores_gemma":[0.9994887,0.00004602514,0.0001541918,0.00007829349,0.00005383286,0.0001789198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005530435,0.00003772373,0.0006561657,0.00006685126,0.00001423431,0.000335144,0.00002222733,0.0001252024,0.9951439,0.0005804718,0.0004288419,0.002036268],"study_design_scores_gemma":[0.00002522257,0.00004373916,0.01260092,0.000007672945,0.00001929666,0.001051036,0.00004094167,0.001184039,0.9795376,0.0004150168,0.005059681,0.00001485922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746419,0.005516097,0.009191629,0.00105893,0.0002826288,0.00004142642,0.002302037,0.001055589,0.005909818],"genre_scores_gemma":[0.9880915,0.0008904032,0.002245668,0.0001377836,0.0000237317,0.00001638232,0.002088563,0.0001781177,0.006327992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003798513,"threshold_uncertainty_score":0.01270729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847593035820968,"score_gpt":0.2780312002011107,"score_spread":0.249555269842901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}